病理状态中药四性数学模型建立及小柴胡汤验证研究  

Establishment of mathematical model for four natures of Chinese materia medica in pathological state and verification on Xiaochaihu Decoction

作　　者：杨岩涛[1,2] 田静[1] 吴春英[3] 王海琴[1] 刘文龙[1,2] 石继连[1] 贺福元[1,2] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南省"十二五"省级药学重点学科,湖南长沙410208 [3]湖南中医药大学管理与信息工程学院,湖南长沙410208

出　　处：《中草药》2014年第1期69-74,共6页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究发展计划资助项目(2007CB512603);国家自然科学基金资助项目(81073142;81173558;30901971;81270055);高等学校博士学科点专项科研基金资助项目(20124323110002);湖南省自然科学基金资助项目(13JJ5032);湖南省"十二五"省级药学重点学科资助项目(1007);长沙市科技计划资助项目(K1109035-31)

摘　　要：目的建立并初步验证病理状态中药四性数学模型。方法用HR3000数显热量计测量小柴胡汤及寒证小鼠模型服药前后体内代谢产物的燃烧焓,计算小柴胡汤加减配伍经小鼠体内代谢产物燃烧焓的变化,据此判断药物寒热,验证依据热力学第一定律所建立中药四性数学模型的正确性。结果计算得到寒证模型小鼠各药物组及模型组的燃烧焓值,并判断出黄芩-柴胡组、黄芩-柴胡+甘草组为寒性药物,小柴胡汤组、人参-生姜-大枣-半夏组、人参-生姜-大枣-半夏+甘草组、黄芩-柴胡+人参-生姜-大枣-半夏组为热性药物,甘草组为平性药物。结论所建立的病理状态中药四性数学模型能正确反映小柴胡汤加减配伍对病理机体的寒、热变化,可用来定量反映中药(复方)四性。Objective To establish and initially verify the mathematical model for the four natures of Chinese materia medica （CMM） in pathological state. Methods The combustion enthalpy of Xiaochaihu Decoction （XD） and the in vivo metabolites in mice with cold syndrome before and after treatment was measured using HR3000 Digital Calorimeter, and the enthalpy changes of the in vivo metabolite in mice on drug combinations with or without XD were calculated and analyzed. The cold-heat properties of CMM were judged, and the mathematical model established by the first law ofthermodinamics was validated. Results The combustion enthalpy of the treatment and model groups of ＂mice with cold syndrome＂ was calculated. The Scutellariae-Bupleurum and Scutellariae-Bupleurum ＋ Licorice groups were identified as cold property drugs, XD, Ginseng-Ginger-Jujube-Pinellia, Ginseng- Ginger-Jujube-Pinellia ＋ Licorice, and Scutellariae-Bupleurum ＋ Ginseng-Ginger-Jujube-Pinellia groups were heat property drugs, and Licorice group was fiat property drug. Conclusion The cold or heat changes of body by drug combinations with or without XD could be reflected accurately by the mathematical model of the four natures of CMM in pathological state. The model could be used to quantitatively reflect the four natures of the compound CMM.

关 键 词：中药四性 数学模型 小柴胡汤 燃烧焓 寒证模型 

分 类 号：R285.5[医药卫生—中药学]