雷替曲塞与奥沙利铂在老年晚期结直肠癌患者中的联合应用研究  

Application research of raltitrexed and oxaliplatin in treatment of elderly patients with advanced colorectal cancer

作　　者：陈银芸[1] 廖江涛[1] 吴娟[1] 

机构地区：[1]湖南省马王堆医院消化内科,长沙410016

出　　处：《中国当代医药》2014年第2期78-79,82,共3页China Modern Medicine

摘　　要：目的观察雷替曲塞与奥沙利铂在老年晚期结直肠癌患者中的联合应用价值。方法选择本院2009年1月~2011年6月收治的经临床病理证实的老年晚期结直肠癌患者43例,随机分为研究组和对照组,研究组22例患者给予奥沙利铂联合雷替曲塞化疗,对照组21例患者给予亚叶酸钙+氟尿嘧啶+奥沙利铂联合化疗,两组均以3周为1个周期,治疗2个周期后评价治疗效果及安全性。结果研究组有效率明显高于对照组(P<0.05);两组药物不良反应中血小板减少、周围神经毒性、脱发、转氨酶异常、腹泻等差异无统计学意义(P>0.05),研究组疲劳、恶心呕吐发生率明显低于对照组,差异有统计学意义(P<0.05)。结论雷替曲塞与奥沙利铂在老年晚期结直肠癌患者中的近期疗效优于标准方案,且患者消化道不良反应较轻,值得应用。Objective To investigate the application value of rahitrexed and oxaliplatin in treatment of elderly patients with advanced colorectal cancer.Methods 43 cases of elderly patients with advanced colorectal cancer confirmed by pathology in our hospital from January 2009 to June 2011 were selected and divided into study group and control group,22 patients in study group were treated with oxaliplatin platinum and raltitrexed chemo-therapy,control group was given fluorouracil ＋ leucovorin ＋ oxaliplatin combination chemo-therapy,three weeks as a period,the therapeutic effica- cy and safety was evaluated after two cycles treatr^ent.Resuits The efficiency rate of study group was significantly high- er than that of the control group （P〈0.05）;adverse drug reactions in the two groups such as thrombocytopenia,peripheral neurotoxicity,alopecia,transaminase abnormalities,diarrhea,had no significant difference （P〉0.05）.The incidence of fa- tigue,nausea and vomiting in study group was significantly lower than that in the control group,the difference was signif- icant （P〈0.05）.Conclusion The short-term effect of raltitrexed and oxaliplatin for advanced colorectal cancer in the el- derly patient is better than the standard program term and gastrointestinal adverse reactions in patients are mild,is wor- thy of application.

关 键 词：雷替曲塞 奥沙利铂 老年 结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤]