瑞舒伐他汀治疗脑梗死合并颈动脉粥样硬化斑块的效果观察  

Effect observation of rosuvastatin treating cerebral infarction complicated with carotid atherosclerotic plaques

作　　者：杨家民 付宇 

机构地区：[1]新疆维吾尔自治区墨玉县人民医院内科,新疆墨玉848100 [2]新疆维吾尔自治区于田县人民医院内科,新疆于田848400

出　　处：《中国当代医药》2014年第2期80-82,共3页China Modern Medicine

摘　　要：目的探讨瑞舒伐他汀治疗脑梗死合并颈动脉粥样硬化斑块的I临床效果。方法选择2010年1月。2012年12月在本院住院的发病2周之内的脑梗死患者60例，将其随机分为对照组与观察组．每组各30例。对照组给予肠溶阿司匹林0．1g，1次／d。观察组在对照组治疗的基础上给予口服瑞舒伐他汀20mg／d。治疗前及治疗后6个月检测两组患者的血清总胆固醇（TC）及三酰甘油（TG）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）；进行颈部血管超声检查，检测颈动脉内中膜厚度（IMT），对两组进行比较。结果对照组治疗前后血脂水平比较．差异无统计学意义（P〉0．05），治疗后，观察组的TC、TG、LDL—C低于治疗前，而HDL—C高于治疗前（P〈0．05）；且TC、TG、LDL-C低于对照组，HDL-C高于对照组（P〈0．05）。治疗前，对照组的颈动脉IMT平均值为（1．59±0．49）mm。治疗后为（1．63±0．43）mm，治疗前后比较，差异无统计学意义（P〉0．05），治疗前，观察组的颈动脉IMT平均值为（1．65±0．39）mm，治疗后为（1．09±0．29）mm，治疗后颈动脉IMT明显低于治疗前，且低于对照组（P〈O．05）。结论瑞舒伐他汀具有降脂作用，可延缓和阻断粥样硬化的进展、稳定斑块、降低脑梗死发生率。Objective To explore the clinical effect of rosuvastatin treating cerebral infarction complicated with carotid atherosclerotic plaques. Methods 60 patients with cerebral infarction with incidence within 2 weeks were selected in our hospital from January 2010 to December 2012,and they were divided into the control group （n=30） and the observa- tion group （n=30）.The control group was given aspirin enteric coated 0.I g,1 time every day,while the observation group was given the oral rosuvastatin 20 mg/d.Before treatment and after 6 months treatment,serum total cholesterol （TC）, triglyceride （TG）,high density lipoprotein cholesterol （HDL-C）,Iow density lipoprotein cholesterol （LDL-C） were detect- ed in both groups.And the neck vascular ultrasound examination was used to detect carotid artery intima-media thick- ness （IMT）. Results In the control group,there was no difference in blood lipid before and after treatment （P〉0.05）.In the observation group,TC,TG,LDL-C after treatment were lower than that before treatment,and HDL-C was higher than that before treatment （P〈0.05）,and TC,TG,LDL-C of the observation group were lower than that in the control group, while HDL-C was higher than that in the control group （P〈0.05）.Before treatment,the average carotid artery IMT was （1.59±0.49） mm,it was （1.63±0.43） mm after treatment,and there was no significant difference before and after treatment （P〉0.05）. In observation group, IMT was （1.65±0.39） mm before treament,after treatment,it was （1.09±0.29） mm,and the IMT after treatment was significantly lower than that before treatment,while the IMT in the observation group after treatment was lower than that in the control group （P〈0.05）. Conclusion Rosuvastatin has the effect of lipid-lowering, and it can delay and block the progress of atherosclerosis,stabilize plaque and reduce the incidence of cerebral infarc- tion.

关 键 词：脑梗死 瑞舒伐他汀 颈动脉内中膜厚度 血脂 

分 类 号：R743.9[医药卫生—神经病学与精神病学]