颅痛定在大鼠急性全脑缺血再灌注损伤中对一氧化氮、内皮素-1及能量代谢的影响  

Influence of rotundine on NO、ET-1 and energy metabolism after acute brain injury resulted from complete cerebral ischemia reperfusion in the rats

作　　者：汤彦[1] 杨光田 蒋崇慧 

机构地区：[1]湖北省十堰市东风汽车公司总医院急诊科,十堰442008 [2]武汉市同济医院急诊科

出　　处：《急诊医学》2000年第6期379-381,共3页

摘　　要：目的 :了解颅痛定在大鼠急性全脑缺血再灌注损伤中对一氧化氮 (NO)、内皮素 1(ET 1)、ATP及乳酸的影响 ,探讨颅痛定 (L THP)对脑缺血再灌注损伤的保护作用。方法 :采用Pulsinelli方法建立大鼠急性全脑缺血再灌注损伤模型。观察L THP在再灌注期间对NO、ET 1及能量代谢的影响。结果 :L THP可以抑制再灌注早期NO、ET 1及乳酸的过量产生 ,提高脑组织ATP含量。结论 :L THP可以通过对NO、ET 1及能量代谢的影响对脑起保护作用。Objective:To find the influence of Rotundine(L THP) on NO、ET 1、ATP and Lactate in rat brain tissues after the global ischemia reperfusion and to investigate protective effects of L THP.Methods:The four vessel occlusion model was made as described by Pulsinelli Brierlog in Sprange Daweley rats.The influences of L THP on NO、ET 1 and energy metabolism during the reperfusion period was observed.Results:L THP can suppress the marked increase of NO、ET 1 and lactate in the early stage of reperfusion,and also improve the contents of ATP.Conclusion:L THP provides remarkable protection against cerebral ischemia reperfusion damage.Its mechanisms may be through its influence on NO、ET 1 and energy metabolism.

关 键 词：颅痛定 脑缺血 再灌注损伤 一氧化氮 内皮素-1 

分 类 号：R743[医药卫生—神经病学与精神病学]