肺腺癌组织中B细胞特异性莫洛氏鼠白血病病毒插入位点基因1表达与患者临床指标及预后的相关性  

Correlations between B-cell-specific moloney leukemia virus insert site 1 expression and clinic.pathological factors and prognosis of patients with lung adenocarcinoma

作　　者：张雪艳[1] 王慧敏[1] 楼煜清[1] 金波[1] 韩宝惠[1] 

机构地区：[1]上海市胸科医院呼吸内科,200030

出　　处：《中国医药》2014年第1期32-36,共5页China Medicine

摘　　要：目的检测肺腺癌组织中B细胞特异性莫洛氏鼠白血病病毒插入位点1（Bmil）表达，并分析其与肺腺癌患者的转移、疗效及预后的相关性。方法免疫组织化学方法检测肺腺癌组织Bmil表达。r检验分析Broil表达与临床病理指标的关系，以Kaplan—Meier生存曲线计算生存率，采用Cox分析评估各指标与患者生存之间的关系。结果126例肺腺癌组织中，72例可观察到Bmil阳性细胞，阳性率为57．1％。Broil表达与肺腺癌患者转移及化疗疗效密切相关（P=0．000或P=0．021），且与患者无病生存期和生存期呈明显负相关。多因素分析结果显示，转移、Bmil表达以及转移后化疗疗效均是影响生存时间的独立因素[β值分别为-6．212、1．015、0．867，95％置信区间分别为0．000～0．019、1．727～4．405、1．680～3．372，均P=0．000]。结论Bmil表达与肺腺癌患者的转移及化疗耐药相关，提示预后不良。Objective To detect the B-cell-specific moloney leukemia virus insert site 1 （Bmil）expression in lung adenocarcinoma tissues, and to analyze its relevance to the metastasis, chemotherapeutic effect and prognosis in lung adenocarcinoma patients. Methods The Bmil expression in lung adenocarcinoma tissues was detected by immunohistochemical methods. The relationship between Broil expression and clinical pathological indicators was examined by ehi-square test. The survival rate was calculated by Kaplan-Meier survivorship curve. The relevance between the indicators and the patient survival was estimated by COX analysis. Results Among the 126 lung adenocarcinoma tissue samples, Bmil positive cells were found in 91 tissues and the positive rate was 57.1%. Bmil expression was closely related to the metastasis and chemoresistance in lung adenoearcinoma patients（ P = 0. 000 or P = 0. 021 ）, and it was in significant negative correlation with the disease free survival period and survival period of the patients. The results of multiple factor analysis showed that transfer, the expression of Broil and the effect of chemotherapy after transfer were the independent influencing factors of the survival time[β = - 6. 212, 1. 015, 0. 867, respectively, and the 95% confidence interval： 0. 0004）. 019, 1. 727-4. 405, 1. 680- 3. 372, respectively, and all P = 0. 000 ]. Conclusion Broil expression is related to the metastasis and chemoresistance in lung adenocarcinoma patients and indicates a poor prognosis.

关 键 词：肺肿瘤 B细胞特异性莫洛氏鼠白血病病毒插入位点1 预后 

分 类 号：R734.2[医药卫生—肿瘤]