凝血和纤维蛋白溶解指标监测对脑梗死患者的临床意义  

Clinical significance of blood coagulation and fibrinolysis marker detection in patients with cerebral infarction

作　　者：滕凤猛[1] 高峰[1] 余清[1] 邓亚静[2] 

机构地区：[1]南京中医药大学附属江苏省中医院,江苏南京210029 [2]江苏大学基础医学与医学技术学院,江苏镇江212013

出　　处：《国际检验医学杂志》2014年第2期184-185,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨脑梗死患者凝血和纤维蛋白溶解指标的变化对临床治疗及预后判断的临床应用价值,以指导临床用药及对脑梗死疾病治疗过程的监测和患者预后的判断。方法采用法国STGAO全自动血凝仪对脑梗死患者的凝血谱进行监测,凝血4项采用磁珠法;D-D二聚体应用免疫比浊法检测。结果脑梗死组与正常组相比PT、Fib、D-D明显增高(P<0.01);APTT、TT无明显差异(P>0.05)。其中D-D二聚体增高最明显,而且D-D二聚体明显升高的患者预后大多有后遗症。结论监测脑梗死患者凝血谱的变化有利于对患者病情的评估和指导临床制定合理的治疗方案,并对患者的预后评估有一定的参考价值。Objective To investigate the clinical significance of blood coagulation and fibrinolysis marker detection for therapy monitoring and prognostic judgment in patients with cerebral infarction. Methods Use France STGAO automatic blood coagulation analyzer to detect blood coagulation appearance,and blood coagulation tetrachoric were detected by magnetic bead methods. D-dim- mer was detected by immunoturbidimetry. Results PT,Fib and l^dimmer, the cerebral infarction group were higher than that of normal group,and there was statistical significance （P^0.01）. Patients with D-dimmer increase most had sequela. APTT and TT had no statistical significance（P＂〉0.05）. The increase of D-dimmer was most obvious, and the patients with D-dimmer increase most had sequela. Conclusion Investigating blood coagulation spectrum variety in cerebral infarction patients profit to guide clinical institution reasonable therapeutic schedule, and to assess patients prognostic.

关 键 词：脑梗死 纤维蛋白纤维蛋白原降解物 纤维蛋白原 

分 类 号：R743.33[医药卫生—神经病学与精神病学]