鼠双微体基因2多态性309T/G与非小细胞肺癌易感性关系的Meta分析  

Association between single nucleotide polymorphism of 309 T/G in murine doubleminute 2 gene and the susceptibility of non-small cell lung cancer:a Meta-analysis

作　　者：乔光磊[1] 祁伟祥[1] 郑水儿[1] 沈赞[1] 姚阳[1] 

机构地区：[1]上海交通大学附属第六人民医院肿瘤内科,上海200233

出　　处：《肿瘤》2014年第1期84-90,共7页Tumor

基　　金：国家自然科学基金资助项目(编号:81001192)

摘　　要：目的：综合评价鼠双微体基因2（murine doubleminute2，MDM2）启动子309位点的单核苷酸多态性（single nucleotide polymorphism，SNP）与非小细胞肺癌易感性的关系。方法：应用计算机检索Cochrane Library、PubMed、EMBase、中国知网、万方和维普等数据库，按照文献纳入标准和排除标准选择研究文献，评价文献质量，并提取资料。采用STATA12．0软件进行Meta分析，计算MDM2SNP309T／G与qH,细胞肺癌易感性关系的合并比值比（oddsratio，OR），并进行亚组分析、敏感性分析和发表偏倚检验。结果：最终纳入8项病例对照研究，共包括5343例患者和6652例正常对照。Meta分析结果显示，MDM2SNP309GG显著增加了tbd,细胞肺癌的发病风险[TTwGG，OR=0．77，95％可信区间（confidence interval，CI）=0．62～0．96；GT珊GG，0R=0．83，95％CI：0．75～0．92：TT＋GTwGG，OR=0．82，95％CI=0．75～0．911。在种族亚组分析中，MDM2SNP309GG显著增加了亚洲人群非小细胞肺癌的发病风险[TTVSGG，OR=0．62，95％CI=0．52～0．73；GT vs GG，OR=0．78，95％CI=0．67～0．90；TTvsGG＋GT，OR=0．71，95％CI=0．59～0．86；TT＋GTwGG，OR=0．73，95％CZ=0．63～0．84]。在性别亚组分析中，MDM2SNP309GG显著增加了女性非小细胞肺癌的发病风险[TTVSGG，OR=0．70，95％C7=0．54～0．91；GTVSGG，OR=0．69，95％C7=0．54～0．90；TT＋GTV8GG，OR=0．70，95％CI=0．55～0．891。结论：MDM2SNP309GG是非小细胞肺癌易感性增加的危险因素，尤其是对于亚洲人群和女性人群。Objective： To evaluate the association between a single nucleotide polymorphism （SNP） of 309 T/G in the promoter of murine doubleminute 2 （MDM2） gene and the susceptibility of non-small cell lung cancer （NSCLC）. Methods： A computer-based online search was performed by using Cochrane Library, PubMed, EMBase, China National Knowledge Infrasrtucture （CNKI）, Wanfang database and VIP database. The case-control studies were selected according to defined inclusion and exclusion criteria. After quality evaluation and data abstraction, a meta-analysis was performed by using STATA 12.0 software. The odds ratio （OR） of the association between MDM2 SNP 309T/G and NSCLC susceptibility was calculated. Then the subgroup analysis, sensitivity analysis and publication bias test were performed. Results： A total of 8 case- control studies were eligible for this analysis, including 5 343 NSCLC patients and 6 652 healthy controls. Meta-analysis showed that MDM2 SNP 309GG could significantly increase the risk of NSCLC [TT vs GG, OR = 0.77, 95% confidence interval （CI） = 0.62-0.96; GT vs GG, OR = 0.83, 95% CI = 0.75-0.92; TT＋GT vs GG, OR = 0.82, 95% CI = 0.75-0.91]. In the subgroup analysis of ethnicity, MDM2 SNP 309GG could significantly increase the risk of NSCLC for Asian people [TT vs GG, OR = 0.62, 95% CI = 0.52-0.73; GT vs GG, OR = 0.78, 95% CI = 0.67-0.90;TT vs GG＋GT, OR = 0.71,95% CI = 0.59-0.86; Tr＋GT vs GG, OR = 0.73, 95% CI = 0.63-0.84]. In the subgroup analysis of gender, MDM2 SNP 309GG could significantly increase the risk of NSCLC for female population [TT vs GG, OR = 0.70, 95% CI = 0.54-0.91 ; GT vs GG, OR = 0.69,95% CI = 0.54-0.90; TT＋GT vs GG, OR = 0.70, 95% CI = 0.55-0.89]. Conclusion： MDM2 SNP 309GG may be a potential biornarker for NSCLC risk, particularly for Asian people and women.

关 键 词：癌 非小细胞肺 原癌基因蛋白质c—mdm2 多态性 单核苷酸 疾病易感性 META分析 

分 类 号：R734.2[医药卫生—肿瘤]