初诊鼻咽癌患者血清TGF-β1、PDGF-β水平及其与肿瘤分期的相关性  

The Levels of Serum TGF-β1 and PDGF-β in Untreated Nasopharyngeal Carcinomas and its Association with Staging

作　　者：章步文[1] 黎钢[1] 叶津津[1] 李峥嵘[1] 

机构地区：[1]浙江省湖州市中医院肿瘤科,313000

出　　处：《中国中西医结合耳鼻咽喉科杂志》2013年第6期424-426,436,共4页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的研究初诊鼻咽癌患者血清TGF-β1及PDGF-β水平变化及其与肿瘤分期的关系。方法分别采用放射免疫分析法及酶联免疫吸附试验法(ELISA)法检测30例健康对照者(正常对照组)及61例初诊鼻咽癌患者(患者组,临床TNM分期Ⅰ期7例、Ⅱ期16例、Ⅲ期21例、Ⅳ期17例)血清TGF-β1及PDGF-β水平,分析其与肿瘤分期的相关性。结果与正常对照组比,患者组血清TGF-β1水平明显升高,其值为(46.66±14.10)ug/L,正常组为(8.61±2.55)ug/L,鼻咽癌患者血清PDGF-β水平亦显著升高,其值为(376.72±16.47)ug/L,正常组为(25.33±7.18)ug/L,(P<0.01);血清TGF-β1(Ⅰ期-Ⅳ期分别为:27.91士8.21、34.26±5.56、40.34±7.88、47.57±12.03)及PDGF-β水平(Ⅰ期-Ⅳ期分别为:277.30士31.97、312.68士22.03、360.25±18.89、401.36±14.72)均随TNM分期的递增而逐步升高,其中Ⅳ期较其他各期显著升高(P<0.01,P<0.05);Ⅱ期与Ⅲ期患者血清TGF-β1及PDGF-β水平较Ⅰ期明显升高,差异有统计学意义(P<0.01,P<0.05);Ⅲ期患者血清TGF-β1较Ⅱ期明显升高,差异有统计学意义(P<0.05),但血清PDGF-β水平较Ⅱ期无统计学意义(P>0.05);相关性分析表明,血清TGF-β1与PDGF-β水平呈明显正相关(r=0.763,P<0.01);血清TGF-β1、PDGF-β水平与TNM分期呈明显正相关(r分别为0.667、0.816,P<0.01)。结论初诊鼻咽癌患者血清TGF-β1与PDGF-β明显升高,其升高的程度与临床分期显著相关。Objective To study the changes of serum TGF-β1 and PDGF-O in untreated nasopharyngeal carcinomas and its association with staging. Method The levels of serum TGF-β1 and PDGF-β in β1 patients with untreated nasopharyngeal carcinoma （TNMI7, nlO, III 21, rvl7） and 30 normal healthy controls were detected by ELISA and radio immunoassay. The relationship between serum TGF-β 1, PDGF-β with TNM stage were statistically analyzed. Results Compared with healthy control group, the levels of of serum TGF-β1 （.healthy control group VS patient group： 8.61±2.55 VS 46.66±14.10） and PDGF-~ （healthy control group VS patient group： 25.33±7.18 VS 376.72±16.47）in nasopharyngeal carcinoma patients were increased significantly （P〈0.01, P〈0.05）, which were increased gradually along with the TNM stage （I-IV stage of TGF β1： 27.91±8.21, 34.26±5.56,40.34±7.88, 47.57±12.03 I-IV stage of PDGF-β： 277.30±31.97, 312.68±22.03, 360.25±18.89,401.36±14.72）. The levels of serum TGFB1 and PDGF-β1 instage IV were increased significantly than other stages （P〈0.01, P〈0.05）, which in stage II and I11were increased significantly than stage I. The level of serum TGF-β1 in stage III were increased significantly than stage II （P〈0.05）,but the level of serum PDGF-β was no statistical difference between stage II and stage III （P〉0.05）. The levels of serum TGF-β1 was postively correlated with serum PDGF-β （r=0.763, P〈0.01） ~ The levels of serum TGF β1 and PDGF-β were postively correlated with TNM stage （r=0.667,0.816, P〈0.01）. Conclusions The levels of serum TGF-β1 and PDGF-β were increased in untreated nasopharyngeal carcinoma patients, which increased with the TNM staging.

关 键 词：鼻咽癌 转化生长因子-β1 血小板源性生长因子-β 

分 类 号：R739.63[医药卫生—肿瘤]