肿瘤干细胞与肿瘤血管异质性  

Cancer stem cells and tumor vascular heterogeneity

作　　者：刘志勇[1] 孙保存[1] 

机构地区：[1]天津医科大学肿瘤医院肿瘤研究所病理科,国家肿瘤临床医学研究中心,天津市肿瘤实验重点实验室,天津市300060

出　　处：《中国肿瘤临床》2014年第2期134-137,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:81201648)资助~~

摘　　要：肿瘤血管新生是肿瘤发生和恶性演进过程中基本的生物学过程。传统的血管生成理论认为肿瘤血管新生主要通过由宿主血管网内皮细胞增殖、迁移长入肿瘤组织或由肿瘤组织募集骨髓中的内皮祖细胞增殖、分化为成熟内皮细胞以构建新生血管,即内皮依赖性血管是肿瘤血供的唯一方式。然而越来越多的研究发现肿瘤的微循环网络是异质性的且肿瘤干细胞在肿瘤血管化过程中具有重要作用。本文就肿瘤干细胞(cancer stem cells,CSCs)对不同肿瘤血管新生模式的作用及其作为肿瘤抗血管生成疗法的潜在靶点做一概述,并对肿瘤干细胞促血管生成研究中待解决的问题进行了展望。Neovascularization is the fundamental process during tumorigenesis and tumor malignant progression. According the traditional neovascularization theory, tumor vasculatures are mainly developed through angiogenesis by sprouting from preexisting ves-sels and vasculogenesis via recruitment of endothelial progenitor cells from the bone marrow, and the endothelial-dependant vessels are the only way that provides tumor with blood. However, more and more studies indicate that tumor microcirculation network is heteroge -neous and cancer stem cells （CSCs） play an important role during tumor neovascularization. This review highlights the contribution of CSCs to tumor microcirculation modes and the potential anti-angiogenesis targets. Furthermore, this review presents insights for perti-nent studies in the future.

关 键 词：血管异质性 肿瘤干细胞 血管新生 转分化 血管生成拟态 

分 类 号：R730.2[医药卫生—肿瘤]