干细胞标志物Oct-4在胃癌组织中的表达及其临床意义的Meta分析  

Expression and Clinical Significance of Oct-4 in Gastric Cancer:A Meta-Analysis

作　　者：乔文辉[1] 姚南[1] 王军[1] 

机构地区：[1]兰州大学第一医院普外科,甘肃兰州730000

出　　处：《中国普外基础与临床杂志》2014年第1期76-81,共6页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的系统评价八聚体结合转录因子4（Oct-4）在胃癌组织中的表达及其临床意义。方法通过检索PubMed、EMBASE、WebofScience、中国生物医学文献数据库（CBM）、中文科技期刊全文数据库（VIP）、中国期刊全文数据库（CNKI）及万方数据库，并辅以文献追溯方法，收集国内外发表的关于Oct-4在胃癌组织中的表达及其临床意义的研究，检索时间均为建库时间至2012年10月。由两位研究者按纳入标准和排除标准筛选文献，并评价纳入研究的质量。采用RevMan5．1软件进行Meta分析。结果共纳入了8个研究，包含胃癌病例623例。Meta分析结果显示：胃癌组织中Oct-4的表达阳性率高于正常胃组织（OR=37．50，95％CI：4．76～295．51，P〈0．01）；低分化胃癌组织的Oct-4表达阳性率高于高．中分化组（OR=0．27，95％CI：0．16～0．45，P〈0．01），但胃癌组织的淋巴结转移情况（OR=2．09，95％CI：0．63～6．94，P=0．23）及TNM分期（OR=0．62，95％CI：0．25～1．54，P=0．30）与Oct-4表达的相关性均无统计学意义。结论胃癌组织中Oct-4的表达与胃癌的分化程度相关，说明Oct-4可能在胃癌的发生和发展过程中起重要作用，但其可能与胃癌的淋巴结转移及TNM分期无关。Objective To investigate the expression and clinical significance of octamer-binding transcription factor 4 （Oct-4） in gastric cancer （GC） tissues with recta-analysis. Methods PubMed, EMBASE, Web of Science, CBM, VIP, CNKI, and WanFang Database were searched from their establishment to Oct. 2012 for related studies, to investigate the relationship between expression of Oct-4 and the clinicopathological characteristics of GC. After evaluating methodo- logical quality of studies that met the inclusion criteria, RevMan 5.1 software was used to data analysis. Results Eight studies which enrolled 623 cases of GC were identified. The results of the meta-analysis showed that, as for the positive expression rate of Oct-4, there were significant differences between GC tissues and normal stomach tissues （OR=37.50, 95% CI： 4. 76-295.51, P〈0. 01）, as well as the cell differentiation （OR=0. 27, 95% CI： 0. 16-0. 45, P〈0.01）, for that the positive expression rate of Oct-4 in low differentiation of gastric cancer tissues was higher than those of moderate- high differentation group. But there were no significant differences between GC tissues with lymph node metastasis and non-lymph node metastasis （OR=2.09, 95% CI： 0. 63-6. 94, P=-0.23）, as well as Ⅰ-Ⅱ stage and Ⅲ-Ⅳ stage （OR=0. 62, 95% CI： 0. 25-1.54, P=-0. 30） of GC tissues. Conclusions Oct-4 may participate in the whole course of carcinogenesis of GC, but the relationship between expression of Oct-4 and lymph node metastasis as well as the TNM stage of GC is unclear, which needs more high quality studies to explore the question clearly.

关 键 词：八聚体结合转录因子4 胃癌 肿瘤干细胞 META分析 

分 类 号：R735.2[医药卫生—肿瘤]