血浆纤维蛋白原水平与大肠癌淋巴结转移相关性的临床研究  

High Preoperative Plasma Fibrinogen Levels are Associated with Lymph Node Metastasis in Patients with Colorectal Cancer

作　　者：魏星[1] 张琪[1] 裘华森[1] 

机构地区：[1]浙江中医药大学附属第一医院胃肠外科,杭州310006

出　　处：《医学研究杂志》2014年第1期44-46,共3页Journal of Medical Research

基　　金：浙江省中医药科技计划基金资助项目(2007CA015)

摘　　要：目的探讨血浆纤维蛋白原（FIB）水平与大肠癌淋巴结转移的关系。方法回顾性分析笔者医院2008～2012年确诊大肠癌无远处转移患者行手术治疗80例，术前测取血浆FIB值，术中记录肿瘤大小及淋巴结转移情况，并与术后病理对照，评价两者关系。结果FIB水平与大肠癌是否发生淋巴结转移有明显相关性（P〈0．05），而与患者年龄，肿瘤部位，浸润深度无统计学差异。Logistic回归分析显示高FIB血症（〉382．25mg／dl）是大肠癌患者淋巴结转移的重要影响因素。结论高FIB血症是大肠癌淋巴结转移的高危险因素，可以作为预测大肠癌淋巴结状态的有效指标。Objective To investigate the relationship between the level of plasma fibrinogen （FIB） with lymph node metastasis in colorectal cancer. Methods Preoperative plasma fibrinogen levels were examined in 80 patients who underwent surgery for colorectal cancer at the First Affiliated Hospital of Zhejiang Chinese Traditional Medicine University from 2008 to 2012. Preoperative plasma fibrino- gen levels were correlated with elinicopathologic findings. Results There was a positive correlation between high plasma fibrinogen levels and the lymph node involvement of colorecta] canee （ P 〈 0.05 ） , but not correlated to the age, tumor location, and the depth of tumor in- vasion. Logistic regression analysis demonstrate that hyperfibrinogenemia （ 〉 382.25mg/dl） was independently associated with lymph node metastasis. Conclusion Our results support the idea that hypcrfibrinogenemia can increase the risk of lymphatic metastasis in pa- tients with colorectal cancer. Hyperfibrinogenemia can be served as an useful biomarker to predict lymph node metastasis.

关 键 词：纤维蛋白原 大肠癌 淋巴结转移 

分 类 号：R735[医药卫生—肿瘤]