B7-H4在上皮性卵巢癌中的表达及意义  

Expression of B7-H4 in epithelial ovarian carcinoma and its significance

作　　者：张羽[1] 陈曾燕[1] 

机构地区：[1]江苏南通南通市肿瘤医院妇科,226000

出　　处：《临床肿瘤学杂志》2013年第12期1104-1107,共4页Chinese Clinical Oncology

摘　　要：目的探讨上皮性卵巢癌组织中B7-H4的表达及其与临床病理特征和预后的关系。方法采用免疫组化法检测66例上皮性卵巢癌、5例交界性卵巢肿瘤、8例良性卵巢肿瘤组织和20例正常卵巢组织蜡块中B7-H4的表达,分析其表达与上皮性卵巢癌临床病理特征和预后的关系。结果 B7-H4在上皮性卵巢癌组织中的阳性表达率为86.4%,在卵巢交界性肿瘤、卵巢良性肿瘤及正常卵巢组织中均不表达。B7-H4在浆液性囊腺癌、子宫内膜样癌和透明细胞癌中的阳性表达率分别为100.0%、90.0%和87.5%,均高于其在黏液性囊腺癌中的50.0%,差异有统计学意义(P<0.05)。上皮性卵巢癌中B7-H4的表达与年龄、腹水细胞学无关,而与临床FIGO分期、组织学分级、淋巴结转移有关。B7-H4的表达与上皮性卵巢癌患者的生存情况无关(P>0.05)。结论 B7-H4蛋白在上皮性卵巢癌组织中的表达上调,其表达与上皮性卵巢癌的发生、发展有关。Objective To detect the expression of B7-H4 in epithelial ovarian carcinoma,and analyze the relationship between B7-H4 and clinical pathological characteristics,prognosis of epithelial ovarian carcinoma.Methods The expression of B7-H4 protein was examined in 66 cases of epithelial ovarian carcinoma,5 cases of border line ovarian tumors,8 cases of benign ovarian tumors and 20 normal ovary tissues by immunohistochemical technique.The association between the expression of B7-H4 protein and clinicopathological characteristics,prognosis in patients with epithelial ovarian carcinoma was further analyzed.Results The positive expression rate of B7-H4 in epithelial ovarian carcinoma was 86.4%,while it did not express in borderline ovarian tumors,benign ovarian tumors and normal ovarian tissue.The positive rates of B7-H4 protein in serous adenocarcinoma,endometrioid carcinoma and clear cell carcinoma were 100.0%,90.0% and 87.5%,higher than 50.0% in mucinous-carcinomas（P 〈 0.05）.The positive rate of B7-H4 protein was related with clincal stage,histological grade and lymphatic metastasis,but not with age and ascites-cytology.B7-H4 was not correlated with survival of patients （P 〉 0.05）.Conclusion The expression of B7-H4 is up-regulated in epithelial ovarian carcinoma,and it plays an important role in the occurrence and development of epithelial ovarian carcinoma.

关 键 词：上皮性卵巢癌 免疫组织化学法 B7-H4 

分 类 号：R737.31[医药卫生—肿瘤]