子宫内膜腺癌中OPN和VEGF-C的表达及意义  

Expression of osteopontin and vascular endothelial growth factor C in endometrial adenocarcinoma

作　　者：张岩[1] 佟盛春[1] 魏力[1] 

机构地区：[1]中国医科大学附属第四医院妇科,辽宁沈阳110032

出　　处：《中国现代医学杂志》2013年第33期37-41,共5页China Journal of Modern Medicine

摘　　要：目的检测骨桥蛋白(OPN)和血管内皮生长因子C(VEGF-C)在正常子宫内膜及子宫内膜腺癌组织中的表达情况,探讨其与子宫内膜腺癌的发生、发展的关系。方法采用免疫组织化学SP染色法,检测OPN和VEGF-C在15例正常增殖期子宫内膜组织(NE)、22例子宫内膜不典型增生组织(AH)及75例子宫内膜腺癌组织(EC)中的表达。并评价其与子宫内膜腺癌临床病理特征的关系。结果 OPN和VEGF-C的表达从正常增殖期子宫内膜到子宫内膜腺癌的发展过程中逐渐增高,差异有显著性(P<0.05)。OPN和VEGF-C的表达随肿瘤的分化降低而增加,同时在肿瘤的肌层浸润及淋巴结转移等方面比较均有显著差异(P<0.05)。结论 OPN和VEGF-C在子宫内膜腺癌中呈明显阳性表达,与子宫内膜腺癌的发生、发展有密切关系,能够反映肿瘤的恶性程度,对其二者的检测将有助于判断患者的病情和预后。【Objective】To evaluate the expression of osteopontin（OPN） and vascular endothelial growth factor C（VEGF-C） in normal, atypical hyperplastic endometrium, and endometrial adenocarcinoma. To explore the relation- ship between the expression of OPN, VEGF-C and the genesis and development of endometrial adenocarcinoma. 【Methods】In this study, to investigate the expressions of OPN and VEGF-C using immunohistochemistry in normal proliferative endometrium（NE, n =15）, atypical hyperplasia（AH, n =22）, and endometrial adenocarcinoma（EC, n = 75）. The relation of OPN, VEGF-C expression and clinical-pathological characteristics was evaluated. 【Results】 The scores of immunostaining increased significantly from NE to the adenocarcinomas（P 0.05）. Expression of OPN and VEGF-C was significantly correlated with tumor grade, myometrial invasion and lymphatic metastasis of en- dometrial carcinoma（P 0.05）.【Conclusions】This study shows that OPN and VEGF-C are significantly highly ex- pressed in endometrial adenocarcinoma. And they are closely associated with the development of endometrioid ade- nocarcinoma.

关 键 词：骨桥蛋白(OPN) 血管内皮生长因子C(VEGF-C) 子宫内膜腺癌 病理学 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]