幽门螺杆菌感染与脑梗死相关性的Meta分析  

Meta-analysis on relationship among Helicobacter pylori infection and cerebral infarction

作　　者：于海燕[1,2] 罗影[1] 张国荣 闵连秋[1] 

机构地区：[1]辽宁医学院附属第一医院神经内科,辽宁锦州121001 [2]锦州市中心医院神经内科 [3]盘锦市中心医院,辽宁盘锦124000

出　　处：《中风与神经疾病杂志》2014年第1期40-43,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨幽门螺杆菌感染与脑梗死发病之间的关系。方法检索MEDLINE、EMbase、Cochrane Collaboration database、中国期刊全文数据库及维普中文科技期刊全文数据库,纳入相关的病例-对照研究的文献。采用RevMan5.0软件进行Meta分析;同时进行文献的异质性检验、敏感性分析以及发表偏倚分析。结果共纳入22篇相关文献,Meta分析结果显示,HP阳性感染有增加脑梗死发病风险的趋势[OR=2.21,95%CI(1.85,2.24),P<0.001]。异质性检验示幽门螺杆菌阳性与脑梗死的研究存在一定异质性(χ2=42.4,P=0.004,I2=50%)。敏感性分析示结果较稳定。漏斗图分析示存在发表偏倚。结论幽门螺杆菌感染是脑梗死的危险因素。Objective Studies have shown that the incidence of Helicobacte pylori （HP） chronic infection in patients with cerebral infarction. But the results are inconsistent. In this study we investigate the relationship among between Helicobacter pylori（HP）infection and cerebral infarction. Methods The relevant case-control studies at MEDLINE,EMbase, Cochrane Collaboration database, CNKI and VIP database were searched. Meta-analysis was performed for the included studies by RevMan5.0 software after strict screening. The performed heterogeneity test, sensitivity analysis and publication bias assessment were also carried out. Results Twenty-two studies were included in this study,tThe results of meta-analy sis revealed that the HP infection had a trend of increasing the risk of cerebral infarction. [ OR = 2.21,95% CI（ 1.85, 2.24）, P 〈 0.01 ], Heterogeneity test found that there was non-significant heterogeneity （X2 = 42.4, P = 0. 004, I2 = 50% ）. Sensitivity analysis suggested that the results of meta-analysis were reliable. The funnel plot suggested that the non-signifi cant presence of publication bias. Conclusions HP infection is one of the risk factors for cerebral infarction.

关 键 词：幽门螺杆菌 感染 脑梗死 META分析 

分 类 号：R743[医药卫生—神经病学与精神病学]