中医辨证治疗结肠癌术后化疗患者的临床分析  

Clinical Analysis of Postoperative Chemotherapy Patients with Colon Cancer Treated by TCM Syndrome Differentiation and Treatment

作　　者：邹波峰[1] 辛世勇 宋海英[3] 樊旭[4] 

机构地区：[1]辽宁省肿瘤医院,辽宁沈阳110000 [2]辽宁省肛肠医院,辽宁沈阳110003 [3]中国医科大学附属盛京医院,辽宁沈阳110004 [4]辽宁中医药大学,辽宁沈阳110847

出　　处：《中华中医药学刊》2014年第2期359-362,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省科技厅项目(2012225018)

摘　　要：目的：探讨中医辨证治疗对结肠癌术后患者的疗效及预后的影响。方法：随机对照研究方法，选取Ⅱ-Ⅲ期结肠癌术后患者74例作为治疗组，以中药协定方为基础，运用中医辨症论治口服汤药配合化疗治疗；同期随机选取Ⅱ～Ⅲ期结肠癌术后患者82例作为对照组，以单纯化疗治疗。比较两组患者的生存情况、复发转移情况及消化道不良反应情况，同时将可能对结肠癌术后的预后产生影响的因素导入Cox风险比例模型进行多因素分析。结果：①治疗组胃肠道不良反应明显低于对照组。②治疗组中位生存期明显长于对照组，且治疗组3年生存率显著高于对照组（P〈0．05），治疗组中位复发及转移率明显低于对照组（P〈0．05）。生存期Cox风险比例模型的多因素分析提示，疾病分期是影响预后的不利因素，中医治疗时间，中医治则中温补肾阳、补血养阴的用药原则是影响预后的有利因素；转移时间Cox风险比例模型的多因素分析提示，中医治疗时间、中医清热利湿，活血解毒治则是影响转移的有利因素。结论：中医辨证治疗可以延长结肠癌术后化疗患者的生存期，改善生存状态，减轻不良反应，特别是温补肾阳、补血养阴的中医治则对患者预后具有一定的积极作用。Objective ： To explore the influence of the curative effect and prognosis of postoperative patients with colon cancer treated by TCM syndrome differentiation. Methods：In the randomized controlled trial,74 cases of postoperative patients with colon cancer in Ⅱ - Ⅲ period were selected as treatment group, with the basis of traditional Chinese medicine agreement prescriptions and the use of syndrome differentiation of traditional Chinese medicine oral liquid form to cooperate with chemotherapy treatment;82 cases of postoperative patients with colon cancer in Ⅱ -Ⅲperiod were selected as the control group with a conventional chemotherapy treatment in a random way at the same time. Reaction conditions of two were compared in survival of patients with status, recurrence, metastasis and gastrointestinal adverse. The conditions of the two groups survival situation, recurrence, transfer and the status of gastrointestinal adverse reaction were compared, and Cox risk scale model imported by the possible factor of the outcomes of colorectal cancer was analyzed by Multiple factors. Results ： （ 1 ） Gastrointestinal side effects of treatment group was lower than that of the control group obviously. （2） The median survival time in the treatment group was obviously longer than that of the control group. The 3 - year survival rate in the treatment group was significantly higher than that of the control group （ P 〈 0.05 ） , and the median recurrence and metastasis rate in treatment group was obviously lower than that of the control group （ P 〈 0.05 ）. （ 3 ） The analysis of multiple factors about Cox risk scale model in life cycle show that the Stage of disease is the unfavorable factors influencing prognosis hut the treatment time of TCM ,The medication principle of TCM of warmly invigorating kidney -yang,e riehing the blood and nourishing yin of TCM are the favorable factors affecting prognosis. The treatment time of TCM, the medication principle of clearing away heat and promoting diuresis , t

关 键 词：中医 辨证治疗 结肠癌 术后 

分 类 号：R735.3[医药卫生—肿瘤]