One-pot Sequential Reaction for the Synthesis of Polysubstituted 3-（3-Nitro-2-phenylchroman-4-yl）-3-arylaminoacrylates  

作　　者：Lili Zhang Jing Sun Chaoguo Yan 

机构地区：[1]College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

出　　处：《Chinese Journal of Chemistry》2013年第12期1546-1550,共5页中国化学（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China，the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘　　要：The one-pot sequential reaction of arylamines, methyl propiolate and 2-aryl-3-nitrochromenes without any catalyst in refluxing ethanol afforded the polysubstituted 3-（3-nitro-2-phenylchroman-4-yl）-3-arylaminoacrylates in good yields and with high diastereoselectivity. Reaction mechanism was believed involving the initial formation of β-enamino ester and sequential Michael addition.The one-pot sequential reaction of arylamines, methyl propiolate and 2-aryl-3-nitrochromenes without any catalyst in refluxing ethanol afforded the polysubstituted 3-（3-nitro-2-phenylchroman-4-yl）-3-arylaminoacrylates in good yields and with high diastereoselectivity. Reaction mechanism was believed involving the initial formation of β-enamino ester and sequential Michael addition.

关 键 词：CHROMENE propiolate ACRYLATE ARYLAMINE one-pot reaction DIASTEREOSELECTIVITY 

分 类 号：O625[理学—有机化学] O626.13[理学—化学]