肝脏肿瘤立体定向放疗的近期疗效  

Short-term Therapeutic Effects of Sterotaxic Radiotherapy for Liver Tumor

作　　者：陈元[1] 胡国清[1] 黄河[1] 

机构地区：[1]同济医科大学附属同济医院肿瘤科,武汉430030

出　　处：《同济医科大学学报》2000年第6期578-580,共3页Acta Universitatis Medicinae Tongji

摘　　要：探讨立体定向放疗对肝脏肿瘤治疗的疗效及影响疗效的因素。对１１例肝脏肿瘤患者，２０个肿瘤病灶进行立体定向放疗，肿瘤临床靶体积（ＣＴＶ）为 １．４～１２６．３ ｃｍ３，中位体积是９．５ｃｍ３。给予计划靶体积（ＰＴＶ）边缘剂量为３０Ｇｙ／２～３次，肿瘤中心剂量为ＰＴＶ边缘剂量的１２０％～１５０％。结果表明随访 ３～２７个月，肿瘤局部缓解率为 ８０．０％，ＣＴＶ≤１０ｃｍ３组与ＣＴＶ＞１０ｃｍ３组完全缓解率分别为６３．６％和０％（Ｐ＜０．０１）；３０ Ｇｙ／２次治疗组与３０ Ｇｙ／３次治疗组完全缓解率分别为５０％和２５％（Ｐ＜０．０１）。治疗中及治疗后副反应很小。表明立体定向放疗是一种治疗肝脏肿瘤安全有效的方法，ＣＴＶ≤１０ｃｍ３组和３０ Ｇｙ／２次治疗组的完全缓解率较高。The therapeutic effects of sterotaxic radiotherapy for liver tumor and the factors influencing them were investigated. Twenty tumor foci of 11 patients with liver tumor underwent sterotaxi radiotherapy. The clinical target volume (CTV) of the tumor was 1.4 to 126.3 cm3 with the median being 9.5 cm3. The giv- en edge dose to the planning target volume (PTV) was 30Gy for 2 to 3 times and the central dose to the tumor was 120 % to 150 % that of the edge dose. The results showed that the tumor local remission rate was 80.0 % during a follow-up of 3 to 27 months. The complete remission rate in the group of CTV≤10 cm3 and the groups of CTV≥10 cm3 was 63.6 % and 0 respectively (P<0. 01). The complete remission rate in the 30 Gy/ 2 times-treated group and the 30 Gy/3 times-treated group was 50 % and 25% respectively (P<0.01). The side effects were mild during and after treatment. It was suggested that sterotaxic radiotherapy for liver tumor was a safe and convenient method. The complete remission rate in the group of CTV≤10 cm3 and the 30 Gy/ 2 times-treated group was higher.

关 键 词：肝肿瘤 立体定向放疗 疗效 放射疗法 

分 类 号：R735.705[医药卫生—肿瘤] R730.55[医药卫生—临床医学]