190例癫痫患者丙戊酸血浓度监测及个体化给药  

Monitoring of the Serum Concentration of Valproic Acid and Drug Administration with Individuation in 190 Epileptic Patients

作　　者：余爱荣[1] 吴笑春[1] 李罄[1] 冷金华[1] 

机构地区：[1]广州军区武汉总医院临床药理科,武汉430070

出　　处：《同济医科大学学报》2000年第6期600-601,共2页Acta Universitatis Medicinae Tongji

摘　　要：采用荧光偏振免疫法对１９０例眼用丙戊酸的癫痫患者进行丙戊酸血浓度监测，分析总结了４１７份血药浓度与剂量及疗效的关系，达到丙戊酸治疗血浓度范围（５０～１００μｇ／ｍｌ）但未有效控制症状的有３４例次，占１５％；不在治疗血药浓度范围内而症状控制良好的有４３例，占２１％。结果表明，丙戊酸血浓度监测对抗癫痫药物合理应用有重要指导作用，但个体化给药还必须综合考虑各方面的因素。The serum concentrations of valproic acid in 190 epileptic patients were determined by using flu- orescence polarization immunoassay. The relations between the serum concentration of valproic acid and the dosage and therapeutic effects in 417 samples were studied. Thirty-four patients with effective serum concentra- tions of valproic acid did not have their epilepsy controlled, accounting for 15 %, while 43 patients whose serum concentrations of valproic acid were below effective level had their epilepsy controlled, accounting for 21%. It was suggested that serum concentration monitoring for valproic acid might play a key role in guiding rational use of antiepileptic drugs and various factors should be considered while practicing the individualized administration of drug.

关 键 词：丙戊酸 血药浓度监测 个体化给药 癫痫 抗癫痫药 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]