细胞色素P450 2E1和畸胎瘤细胞源性生长因子在食管鳞状细胞癌中的表达及临床意义  

Clinicopathologic significance in expressions of cytochrome P450 2E1 and PC cell-derived growth factor in esophageal squamous cell carcinoma

作　　者：陈宏超[1] 梁倩萍[2] 杨德生[3] 方立峰[1] 

机构地区：[1]郑州市第一人民医院消化内科,450000 [2]郑州市中心医院消化内科 [3]河南大学附属淮河医院消化内科

出　　处：《肿瘤研究与临床》2013年第12期793-795,805,共4页Cancer Research and Clinic

摘　　要：目的 探讨食管鳞状细胞癌（ESCC）中细胞色素P450 2E1（CYP2E1）、畸胎瘤细胞源性生长因子（PCDGF）的表达与肿瘤临床病理参数之间的关系.方法 选择郑州市第一人民医院外科2007年7月至2011年5月间手术切除ESCC标本42例及20例癌旁正常组织.采用免疫组织化学方法检测食管鳞状上皮中C YP2E1与PCDGF的表达.结果 ESCC中CYP2E1、PCDGF的阳性表达率分别为83.3％（35/42） 、88.1％（37/42）,均较正常食管上皮明显增加（P＜ 0.05）;PCDGF与肿瘤的组织分化程度（r=0.444,P＜ 0.05）、浸润深度（r=0.332,P＜0.05）、淋巴结转移（r=0.476,P＜0.05）和TNM分期（r=0.450,P＜ 0.05）有关;CYP2E1的表达与肿瘤的组织分化程度呈负相关（r=-0.518,P＜0.05）,而与浸润深度呈正相关（r=0.388,P＜ 0.05）.CYP2E1和PCDGF在肿瘤中的表达有相关性（r=0.483,P＜ 0.05）.结论 ESCC中CYP2E1和PCDGF相互协同参与了肿瘤生长、浸润和转移,可能成为判断食管癌生物学行为及患者预后的重要指标.Objective To investigate the relationships and clinicopathologic features of the expressions of cytochrome P450 2E1 （CYP2E1） and PC cell-derived growth factor （PCDGF） in esophageal squamous cell carcinoma （ESCC）,and to determine the role of CYP2E1 and PCDGF in angiogenesis.Methods The expression levels of CYP2E1 and PCDGF in 42 surgical cancer specimens and 20 adjacent normal esophageal mucosa specimens from patients with ESCC were detected by immunohistochemistry.Results The positive expression rates of CYP2E1 and PCDGF in ESCC were 83.3 ％ （35/42） and 88.1％ （37/42）,respectively,which were obviously higher than those of normal mucosa （P ＜ 0.05）.Expression of PCDGF was correlated with the degree of histological differentiation （r =0.444,P ＜ 0.05）,depth of tumor invasion （r =0.332,P ＜ 0.05）,lymph node metastasis （r =0.476,P ＜ 0.05）,and TNM classification （r =0.450,P ＜ 0.05）.The expression of CYP2E1 was negatively correlated with tumor tissue differentiation （r =-0.518,P ＜ 0.05）,and positively correlated with depth of invasion in ESCC （r =0.388,P ＜ 0.05）.The expression of CYP2E1 was related to that of PCDGF in the tumor （r =0.483,P ＜ 0.05）.Conclusion The expressions of CYP2E1 and PCDGF are synergistically involved in tumor growth,infiltration andmetastasis.Overexpression of CYP2E1 and PCDGF can be used as the important predictors for evaluating the biological behavior of ESCC and predicting prognosis of patients.

关 键 词：食管肿瘤 癌 鳞状细胞 细胞色素P450 CYP2E1 畸胎瘤细胞源性生长因子 

分 类 号：R735.1[医药卫生—肿瘤]