环氧化酶-2-765G＞C基因多态性与结直肠癌易感性关系的Meta分析  

Cyclooxygenase-2-765G 〉 C polymorphism and susceptibility to colorectal cancer： a meta-analysis

作　　者：陈曦[1] 董卫国[1] 王军[1] 吕晓光[1] 雷宏博[1] 刘娅[1] 

机构地区：[1]武汉大学人民医院消化内科,430060

出　　处：《中华预防医学杂志》2014年第1期62-66,共5页Chinese Journal of Preventive Medicine

摘　　要：目的 探讨环氧化酶-2（COX-2）-765G＞C基因多态性与结直肠癌（CRC）易感性的关联.方法 计算机检索Pubmed、EMABSE、CJFD、CBM、CNKI、VIP及万方数据库,检索时间截至2013年3月1日,收集关于COX-2-765G＞C基因多态性与结直肠癌易感性的病例-对照研究,初筛得到99篇文献.由2名评价者按照纳入和排除标准独立选择文献、提取资料、评价质量,采用RevMan 5.1和Stata12.0软件进行Meta分析.结果 最终纳入11个病例-对照研究,包括3432例患者和5286名对照.纳入的结果除在GC/GG基因型的比较模型中存在异质性（I2 =52％,P=0.03）外,其他三种遗传模型同质性较好.各遗传模型Meta分析结果显示：COX-2-765G＞C基因多态性与结直肠癌易感性的关联性无统计学意义[显性遗传模型：（GC＋ CC）/GG：OR=1.08,95％ CI：0.96 ～ 1.21;隐性遗传模型：CC/（GC＋ GG）：OR=1.09,95％ CI：0.76～ 1.56;共显性遗传模型：GC/GG：OR=1.05,95％ CI：0.87 ～ 1.28;CC/GG：OR=1.11,95％ CI：0.77～1.60].基于人群的亚组分析显示：COX-2-765G＞C基因多态性可增加黄种人群罹患结直肠癌的风险[（GC＋ CC）/GG：OR=1.41,95％ CI：1.15 ～ 1.75;GC/GG：OR=1.48,95％ CI：1.15～1.90],而对白种人群结直肠癌易感性无明显关联.结论 COX-2-765G＞C基因多态性可增加黄种人群结直肠癌的易感性.Objective To explore the correlation between polymorphism of cyclooxygenase-2 （COX-2）-765G ＞ C and susceptibility to colorectal cancer.Methods All eligible case-control studies published up to March 2013 were searched out from PubMed,EMABSE,CJFD,CBM,CNKI,VIP and WanFang databases,while 99 articles were concluded.Two reviewers independently identified the literature according to inclusion and exclusion criteria.Meta-analysis was performed using RevMan 5.1 and Stata 12.0 software.Results A total of eleven studies comprising 3432 cases and 5286 controls were finally included.The included studies showed good homogeneity in the three genetic models,except the model of GC/GG genotype （I2 =52％,P =0.03）.Overall,there were no significant association between polymorphism of COX-2-765 G ＞ C and the susceptibility to colorectal cancer （dominant model：（GC ＋ CC）/GG：OR =1.08,95％ CI：0.96-1.21 ; recessive model：CC/（GC ＋ GG）：OR =1.09,95％ CI：0.76-1.56; GC/GG：OR =1.05,95％ CI：0.87-1.28; CC/GG：OR =1.11,95％ CI：0.77-1.60）.In stratification analysis by ethnicity,we observed that the polymorphism of COX-2-765G ＞ C could increase the susceptibility to colorectal cancer among yellow populations （（GC ＋ CC）/GG：OR =1.41,95％ CI：1.15-1.75 ; GC/ GG：OR =1.48,95％ CI：1.15-1.90）,but there was no significant association found among Caucasian populations.Conclusion This meta-analysis suggested that the polymorphism of COX-2-765G ＞ C may increase the susceptibility to colorectal cancer in the yellow population.

关 键 词：环氧化酶2 结肠肿瘤 META分析 多态现象 遗传 

分 类 号：R735.34[医药卫生—肿瘤]