蛛网膜下腔出血后血浆t-PA、PAI-1变化的临床意义  

Changes and clinical value of plasma t-PA and PAI-1 of patients with subarachnoid hemorrahage

作　　者：李宪章[1] 宓现强[1] 阮喜云[1] 靳光娴[1] 孙卓祥[1] 

机构地区：[1]济宁医学院附属医院,山东济宁272029

出　　处：《山东医药》2001年第1期6-8,共3页Shandong Medical Journal

摘　　要：对 2 8例蛛网膜下腔出血 (SAH)后患者的血浆组织型纤溶酶原激活物 (t- PA)、纤溶酶原激活物抑制物 (PAI- 1)变化进行了观察 ,并与 30例健康者进行对照。结果显示 ,与对照组比较 ,SAH后 1～ 14天患者血浆纤溶活性明显增高 ;其中伴发脑血管痉挛 (CVS)者出血第 7天、 14天血浆 PAI- 1活性均明显高于无 CVS者 ;出血量多者血浆 t- PA、PAI- 1活性较高。提示血浆 t- PA、PAI- 1活性在 SAH后呈动态变化 ,二者可能均参与 SAH的发生、发展 ,其活性测定可望成为监测 SAH、 CVS及出血量的有效指标。The plasma tissue type plasminogen activator(t PA),plasminogen activator inhibitor 1(PAI 1)in 28 patients with subarachnoid hemorrhage(SAH) were observed and compared with 30 healthy controls Result showed that the fibrinolytic activity of patients with SAH on day 1～14 were significantly higher than that of normal controls Plasma PAI 1 activity of patients with cerebral vascular spasma(CVS) were higher than those without CVS on day 7,14 The more was the amount of bleeding,the more were the levels of t PA and PAI 1 It suggests that the activity of plasma t PA and PAI 1 are dynamic changing Both of them may involve in the development and prognosis of SAH Determination of t PA and PAI 1 are efficient items for early finding,diagnosis of CVS and amount of bleeding in patients with SAH

关 键 词：蛛网膜下腔出血 组织型纤溶酶原激活物 纤溶酶原激活物抑制剂-1 T-PA PAI-1 

分 类 号：R743.350.2[医药卫生—神经病学与精神病学]