生长抑素受体亚型SSTR-2和SSTR-3mRNA在原发性肝癌中的表达  

Somatostatin Receptor Subtype SSTR-2and SSTR-3mRNA Expression in Primary Hepatic Carcinoma

作　　者：颜登国[1] 区庆嘉[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院外科,广州510120

出　　处：《癌症》2001年第2期152-155,共4页Chinese Journal of Cancer

摘　　要：目的:了解原发性肝癌组织中生长抑素受体somatostatinreceptor,SSTR亚型SSTR2和SSTR3基因的表达情况。方法:采用逆转录-PCR法检测27例原发性肝癌患者癌组织和癌旁组织中生长抑素受体亚型SSTR2和SSTR3mRNA的表达。结果:27例原发性肝癌患者的癌组织和癌旁组织SSTR2mRNA的表达阳性率分别为81.5%(22/27)和96.3%(26/27)SSTR3mRNA在肝癌组织中表达的阳性率为66.7%(18/27),在癌旁组织中的阳性率为51.9%(14/27)。结论:大多数原发性肝癌肿瘤组织中有一种以上生长抑素受体亚型基因的表达。Objective:The current study was designed to investigate SSTR subtype gene expression in tissue of primary hepatic carcinoma.Methods :The expression of SSTR-2and SSTR-3m RNA in the tumor tissue of hepatic carcinoma and the adjacent tissue of cancer in 27patients with primary hepatic carcinoma was examined by RT-P CR.Results:The positive rate of expression of SSTR-2mRNA in the tissues of hepatic carcinoma was 81.5%(22/27),and the positive rate of expression in the ad jacent tissues of cancers was 96.3%(26/27).The positive rate of SSTR-3mRNA in tumor tissues and the adjacent tissu es of hepatic carcinoma were 66.7%(18/27)and 51.9%(14/27),respectively.Conclusion:There are more than one SSTR subtype g enes expression in tumor tissues of primary hepatic carcinoma.

关 键 词：肝肿瘤 生长抑素受体 MRNA 亚型SSTR-2 亚型SSTR 

分 类 号：R735.7[医药卫生—肿瘤] R730.231[医药卫生—临床医学]