中国山东沿海地区汉族男性人群白介素-23受体基因多态性与痛风的易感性研究  

Relationship between interleukin- 23 reporter polymorphism and susceptibility to gout in Chinese male population

作　　者：何红梅[1] 宇仁超[2] 任宪峰[3] 王玉[4] 崔莹[1] 李长贵[1,5] 刘世国[5,6] 

机构地区：[1]青岛大学医学院附属医院内分泌与代谢病科 [2]青岛大学医学院附属医院黄岛分院心内科 [3]青岛大学附属医院脊柱外科 [4]青岛大学医学院 [5]青岛大学医学院附属医院痛风病实验室 [6]青岛大学附属医院遗传室,青岛266003

出　　处：《中国优生与遗传杂志》2014年第2期25-27,35,共4页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金(81070686);国家自然科学基金(31371272);山东省自然科学基金(ZR2010HZ001)

摘　　要：目的探讨中国山东省沿海地区汉族男性群体的白细胞介素23受体(IL-23R)基因rs7517847位点G/T的多态性是否与痛风的易感性有关。方法选取202例痛风患者和346例健康对照者,检测中国汉族男性群体的IL-23受体内含子区rs7517847位点基因多态性分布,数据经χ2检验得出其与痛风发病的遗传易感性的关系。结果经χ2检验,痛风组和对照组中IL-23R基因rs7517847位点GG,GT和TT基因型频率(10.4%,49.5%,40.1%;16.2%,49.7%,34.1%;χ2=4.305,P>0.05)与等位基因频率G和T(35.1%,41%;64.9%,59%;χ2=3.727,P>0.05)均无统计学意义。IL-23R基因rs7517847位点G/T基因多态性与痛风病的危险因素无显著性关联。结论尚不能认为中国沿海地区汉族男性人群中IL-23R内含子区rs7517847位点基因多态性与痛风有关联性。Objective： To explore gene polymorphism of the G/T genotype of rs7517847 in the intron of IL - 23R gene in male population living in the coaslal area of Shandong, and thus to investigate the relationship between the gene polymorphism of IL- 23R and gout. Methods： A total of 202 gout patients and 346 healthy controls were enrolled. The possible association between thepolymor- phism of IL- 23R and gout in Chinese was investigated and genotype frequencies and allelic frequencies were calculated by Fluores- cence quantitative PCR Taqman probe technology. Comparisons bctween the groups were performed with X2 test. Results： The fre- quences of GG. GT and TY genotypes were 10.4%, 49. 5% and 40. 1%, respectively among gout patients, while they were 16. 2%, 49. 7% and 54. 1%, respectively among the controls. There was no ststistically difference in IL -23R （G/T） genotype fre- quencies between gout paitents and controls （X2 = 4. 305, P 〉 0. 05）. The allele frenquencies of G and T in gout cases were different from those in the controls （35. 1%, 41% ; 64. 9%, 59% ; X2 = 3. 727, P 〉 0. 05）. In all, no association between IL- 23R （G/T） genotypes and risk factors for gout were observed in gout cases by X2 test. Conclusion： Results of the present study suggest that the G/T genotype of rs7517847 in the intron of IL -23R gene is not associated with gout in male population living in the coastal area of shandong.

关 键 词：IL-23R 多态性 单核苷酸 痛风 

分 类 号：R589.7[医药卫生—内分泌]