食管癌转移淋巴结放免显像定位的临床试验  

Clinical Trial of Radioimmunoimaging of Lymph Node Metastasis in Esophageal Carcinoma

作　　者：林鹏[1] 戎铁华[1] 樊卫[2] 刘长征[3] 何军芳[3] 梁昌盛[3] 徐国良[4] 刘乐和[5] 

机构地区：[1]中山医科大学肿瘤防治中心胸科,广东广州510060 [2]中山医科大学肿瘤防治中心核医学科,广东广州510060 [3]中山医科大学核医学教研室,广东广州510089 [4]中山医科大学肿瘤防治中心内窥镜室,广东广州510060 [5]中山医科大学病原生物学部

出　　处：《癌症》2001年第2期183-186,共4页Chinese Journal of Cancer

摘　　要：目的:探讨放射免疫显像(radioimmunoimaging,RII)在食管癌转移淋巴结定位的临床应用。方法:1.131I标记抗人食管鳞癌单抗G9,形成标记化合物,在胸段食管鳞癌的术前病例,于纤维食管镜下,用纤镜专用注射针,在食管原发灶周围,粘膜下注射131IG9后行RII。2.完成RII后,对清扫淋巴结行放射性测定。结果:1.注药48h时RII在食管旁纵隔、贲门旁、胃小弯旁出现散在的细点状放射性浓集,拟为转移淋巴结所在。2.显像出现散在放射性浓集区域所清扫的淋巴结中,包含有转移淋巴结;无浓集区域,未发现转移淋巴结。3.全部有转移淋巴结的放射性比活度cpm/g均比无转移者高,且均数高出两倍多。结论:用131IG9在食管鳞癌行放射免疫显像,对转移淋巴结有定位作用。Objective:The current study was designed to evaluate the clinical application of ra dioimmunoimaging(RII)for lymph node metastasis in esophag eal carcinoma.Methods:1) 131 I was used to label McAb G9(specific to cellular membrane antigen of human e sophageal carcinoma )and form labeling compound 131 I-G9.Administration of 131 I-G9in esophagus submucosally with a specific injector for the purpose o f submucosal injection via endoscop ies in preoperative patients with squamou s cell carcinoma of thoracic esophag us followed by RII.2)The samples of dissected lymph node were used for detection of radioactivity.Results:1)The pictures at 48h showed that small radioactivity concentrated dots appeared dispers edly in mediastinum and upper abdome n around esophagus and cardiac gastr ic.The lymph nodes were considered metasta tic in above regions.2)The pathological results of the lymp h nodes dissected compared to the RII result.The metastatic lym ph nodes were found in the regions of dispersedly concentrated radioacti vity,while no metastatic lymph nodes could be found in the radioactivity free regions.3)After counting for radioactivity,l ymph node metastases showed higher antibody u ptake than the non-metastases lymph nodes.The difference was statistic ally significant.Conclusion:131 I-G9may be used to locate metastatic lymph nodes in patients with esophag eal carcinoma.

关 键 词：食管肿瘤 淋巴结转移 放射免疫显像 单克隆抗体 碘131 

分 类 号：R735.1[医药卫生—肿瘤] R73－37[医药卫生—临床医学]