Cajal间质细胞在急进高原胃肠动力紊乱中的作用的展望  

Advance on the Study on the Role of Interstitial Cell of Cajal in Gastrointestinal Motility Disorder of Radical Plateau

作　　者：朱琳[1] 贺巍[1] 杨生岳[1] 范兴爱[1] 刘睿年[1] 

机构地区：[1]解放军第四医院消化内科,青海西宁810007

出　　处：《现代生物医学进展》2013年第34期6786-6789,共4页Progress in Modern Biomedicine

基　　金：青海省(应用)基础研究计划项目(2013-Z-760)

摘　　要：急进高原胃肠动力紊乱是高原胃肠应激反应的主要表现之一,腹胀、恶心、呕吐、腹泻、食欲减退等是其最突出的临床症状,目前有关其的研究多集中于临床及部分基础研究上,但在探讨有关高原胃肠动力紊乱形成机制的细胞分子生物学领域的研究则少见报道。而大量研究指出,慢波起源细胞Cajal间质细胞在胃肠动力调控中具有重要作用,并成为的研究的热点,那么Cajal间质细胞是否同样在急进高原胃肠动力紊乱中发挥同样重要的作用,这不但对从细胞分子生物学角度来解释急进高原胃肠动力紊乱的机制有着重要的意义,而且还可以对未来的临床干预提供新的思路。因此,本文拟对Cajal间质细胞在急进高原胃肠动力紊乱中的潜在作用作一综述。High altitude gastrointestinal motility disorder is one of the main manifestations of gastrointestinal stress response of radical plateau. A lots of clinical symptoms are the most prominent, such as abdominal distention, nausea, vomiting, diarrhea, loss of ap- petite, and so on. The present studies for it are focusing on the clinical and a part of basis, but on the molecular biology of the cell of high altitude gastrointestinal motility disorder is seldom reported. Accumulated evidence over last several years indicates an important role of interstitial cells of Cajal in the gastrointestinal motility regulation. Maybe ICCs also can play an important role in the high altitude gas- trointestinal motility disorders. This paper reviewed the lastest investigate on progress on the potential role of ICCs in the gastrointestinal motility regulation.

关 键 词：高原 高海拔 胃肠动力 CAJAL间质细胞 

分 类 号：Q48[生物学—生理学] R57[医药卫生—消化系统]