口服避孕药对中国女性乳腺癌发病风险影响的Meta分析  

Oral Contraceptive May Increase the Risk of Breast Cancer in the Population of Chinese Women:a Meta-Analysis of 19 Case-Control Studies

作　　者：孙莹[1] 孟昭义 孟浩宇[1] 戴辉华[3] 

机构地区：[1]南京医科大学第一临床医学院,江苏南京210029 [2]江苏省新沂市人民医院普外科,江苏新沂221400 [3]南京医科大学第一附属医院妇产科,江苏南京210029

出　　处：《现代生物医学进展》2013年第35期6984-6987,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81070471)

摘　　要：目的:评价口服避孕药对中国女性乳腺癌发病率的影响。方法:计算机及手动检索中国知网,万方,维普,中国生物医学文献数据库,纳入有关口服避孕药对乳腺癌发病影响的研究。在评价纳入研究的方法学质量和提取有效数据后,采用Review Manager5.0进行Meta分析。结果:共纳入19篇病例对照研究,包括例5051患者和6023例对照。Meta分析结果显示:乳腺癌病例组比对照组有着较高的口服避孕药暴露比。结论:口服避孕药可能会增加中国女性乳腺癌的发病风险。Objective： The purpose of this study was to perform a meta-analysis of oral contraceptive and breast cancer to assess whether some relationship can be found between them. Methods： Computerized literature search and hand search were done in CNKI, CBM, WanFang and WeiPu to screen study of oral contraceptive and breast cancer. Quality assessment and Meta analyses were perform- ed for the included studies. Results： Nineteen articles involving 5051 patients were identified. The meta-analyses indicated that case group was associated with a higher exposure ratio to oral contraceptive compared with the control group. Conclusion： Oral contraceptive may increase the risk of breast cancer in the population of Chinese women.

关 键 词：乳腺癌 口服避孕药 META分析 

分 类 号：R737.9[医药卫生—肿瘤]