大鼠脑单胺氧化酶对甲状腺激素反应的实验观察  

Experimental study on the response of monoamine oxidase in the rat brain to thyroid hormone

作　　者：朱燕凌[1] 刘用璋[1] 肖建英[1] 高淑贤[1] 王翠瑶[1] 

机构地区：[1]锦州医学院生化教研室,辽宁锦州121001

出　　处：《中国地方病学杂志》2001年第1期26-27,共2页Chinese Jouranl of Endemiology

摘　　要：目的　探讨甲状腺激素对甲状腺功能低下 (甲低 )鼠脑单胺氧化酶 (MAO)活性的影响和保护作用。方法　用 1% Na Cl O4诱发大鼠甲状腺功能低下 ,实验组大鼠分别注射 T3、T4,观察脑 MAO活性变化 ,同时观察生后不同时期甲低仔鼠 MAO活性。结果　甲低大鼠脑 MAO活性增强 ,2 0日龄仔鼠 MAO活性增加的百分比高于成熟鼠。注射 T4脑 MAO活性恢复 ,脑 MAO活性与血清 T4呈负相关。结论　大鼠甲低时脑 MAO活性变化反映了 MAO在维持大脑发育和功能上起重要作用 ,T4对脑 MAO活性有保持作用。Objective To study the influence of thyroid hormone and protective effect on brain MAO activity in hypothyroid rats.Methods Hypothyroid rats was induced by 1% NaClO 4 and experimental rats received T 3,T 4.The variation of brain MAO activity was observed.At the same time brain MAO activity of hypothyroid rats on the different time after birth also was studied.Results In hypothyroid rats,brain MAO activity showed an increase and the increasing percentage of MAO activity in the 20 day offspring rats was higher than in mature rats.After injecting T 4,MAO activity was recovered,which showed a negative correlation with serum T 4.Conclusions The change of brain MAO activity in hypothyroidism suggested that MAO can play an important role in maintaining the development and function of brain and T 4 has protective effect on brain MAO activity.

关 键 词：甲状腺激素 甲状腺功能低下 脑 单胺氧化酶 大鼠 克汀病 

分 类 号：R363[医药卫生—病理学]