胰岛素样生长因子-Ⅰ受体与增殖细胞核抗原在乳腺癌组织中的表达及其意义  

Expression and significance of insulin-like growth factor-I receptor( IGF-IR)and proliferating cell nuclear antigen( PCNA) in the breast cancer tissue

作　　者：陈钧洁[1] 赵文举[1] 周媛[1] 王咏红[1] 王英丽[2] 

机构地区：[1]解放军第208医院妇产科,吉林长春130000 [2]吉林省肿瘤防治研究所

出　　处：《中国妇幼保健》2014年第4期600-602,共3页Maternal and Child Health Care of China

基　　金：吉林省科技厅自然科学基金资助项目〔201015232〕;吉林省卫生厅课题资助项目〔2011Z035〕

摘　　要：目的:检测胰岛素样生长因子-Ⅰ受体与增殖细胞核抗原在乳腺癌组织中的表达,分析胰岛素样生长因子-Ⅰ受体和增殖细胞核抗原在乳腺癌发生、发展中的作用。方法:选取94例乳腺癌患者,比较乳腺癌组织和癌旁组织中胰岛素样生长因子-Ⅰ受体与增殖细胞核抗原的表达情况,并分析其与肿瘤生物学特性的相关性。结果:胰岛素样生长因子-Ⅰ受体在乳腺癌组织中的阳性例数为80例,阳性率为85.11%,在癌旁组织中阳性率为40例,阳性率为42.55%,胰岛素样生长因子-Ⅰ受体在乳腺癌组织中的阳性表达率明显高于癌旁组织(χ2=35.04,P<0.05)。增殖细胞核抗原在乳腺癌组织中的阳性例数为70例,阳性率为74.47%,在癌旁组织中阳性31例,阳性率为32.98%,增殖细胞核抗原在乳腺癌组织中的阳性表达率明显高于癌旁组织(χ2=30.89,P<0.05)。不同组织学类型胰岛素样生长因子-I受体和增殖细胞核抗原阳性表达率无明显差别(P>0.05)。随TNM分期升高,胰岛素样生长因子-Ⅰ受体阳性率逐渐降低(χ2=0.20,P>0.05),增殖细胞核抗原阳性率逐渐升高(χ2=12.11,P<0.05)。结论:胰岛素样生长因子-Ⅰ受体和增殖细胞核抗原的高表达均是乳腺癌发生、发展过程的重要分子生物学标记,二者可能起到协同作用。增殖细胞核抗原的表达程度可以作为乳腺癌细胞增殖活性和恶性程度的指标之一。Objective： To detect the expression of IGF - IR and PCNA in breast cancer tissue, and to analyze the significance of 1GF - IR and PCNA in the occurrence and development of breast cancer. Methods： 94 cases of patients with breast cancer were selected, the expression of IGF - IR and PCNA in breast cancer tissue and tissue adjacent to carcinoma were detected and its correlation with tumor bi- ological characteristics were analyzed. Results： In breast cancer tissue, the positive cases of IGF - IR were 80 cases, the positive rate was 85.11% , the positive cases in the tissue adjacent to carcinoma were 40 cases, the positive rate was 42. 55% , the positive rate in breast cancer tissue was significantly higher in tissue adjacent to carcinoma, the comparative difference was statistically significant （X2 = 35.04, P 〈0. 05） . In breast cancer tissue, the positive cases of PCNA were 70 cases, the positive rate was 74.47%, the positive cases in the tis- sue adjacent to carcinoma were 31 cases, the positive rate was 32. 98% , the positive rate in breast cancer tissue was significantly higher in tissue adjacent to carcinoma, the comparative difference was statistically significant （X2 = 30. 89, P 〈 0. 05） . The positive rate among dif- ferent histological types of the IGF - IR and PCNA were no difference （P 〉 0. 05 ） . With TNM staging, the positive rate of IGF - IR was gradually reduced （X2 = 0. 20, P 〉 0. 20）, the positive rate of PCNA increased （X2 = 12. 11, P 〈 0. 05 ） . Conclusion： The high expres- sion of IGF - IR and PCNA are the important molecular markers of the breast cancer occurrence, development process, and they may have synergy. The expression degree of PCNA can be used as one of the indicators of the breast cancer cell proliferation activity and malignant de- gree.

关 键 词：乳腺癌 胰岛素样生长因子-Ⅰ受体 增殖细胞核抗原 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]