21例原发性食管小细胞癌的诊断与治疗  

Diagnosis and treatment of 21 cases of primary esophageal small cell carcinoma

作　　者：孟令新[1] 丁兆军[1] 徐美玲[1] 迟玉华[1] 孟芹[1] 

机构地区：[1]济宁医学院附属日照市人民医院肿瘤科,山东日照276826

出　　处：《现代肿瘤医学》2014年第2期323-325,共3页Journal of Modern Oncology

基　　金：山东省自然科学基金资助项目(编号:ZR2010HL053);济宁医学院面上项目(编号:JY2013KY061)

摘　　要：目的:探讨原发性食管小细胞癌的临床特点、治疗及预后。方法:回顾分析21例原发性食管小细胞癌患者的临床资料,分析不同治疗方法的治疗效果,并对21例原发性食管小细胞癌患者肿瘤组织进行常规病理学检查及神经元特异性烯醇化酶(NSE)和嗜铬素A(CgA)免疫组织化学染色。结果:1年生存率60.0%,2年生存率25.0%,3年生存率15.0%。中位生存期16.9个月。21例原发性食管小细胞癌患者组织中NSE和CgA染色呈阳性,其中2例小细胞癌病变中有鳞癌灶性病变。结论:原发性食管小细胞癌应采用以化疗占主要地位的综合治疗,局限期以手术联合化疗,广泛期以放疗联合化疗为宜。NSE和CgA在食管小细胞癌诊断中具有一定作用。Objective： To investigate the clinical characteristics,treatment and prognosis of primary small cell cancer of the esophagus （PSCCE）. Methods：The esophageal cancer tissues were tested by pathological examination and immunohistochemical staining for neuron specific enolase （ NSE ） arid chromogranin A （CgA） . Results ： The 1 , 2 - and 3 - year survival rates were 60.0% ,25.0% and 15.0% respectively. The median smwival time of all the cases was 16.9 months. The NSE and CgA staining were positive in the 21 patients with primary esophageal small call carcinolna,including 2 cases of slnall cell carcinolna lesions in squalnous cell carcinolna lesions. Conelusion：PSCCE should be lnanaged by chelnotherapy - based colnbined therapy. Surgery combined with chelnotherapy in lilnited stage and inextensive stage should be used. NSE and CgA staining has a certain role in the diagnosis of esophageal small cell carcinoma.

关 键 词：食管 小细胞癌 综合治疗 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]