子宫内膜癌患者血清TK1检测的临床意义  

Significance of serum thymidine kinase in patients with endometrium carcinoma

作　　者：徐萍萍[1] 肖梅[1] 陈赛英[1] 

机构地区：[1]解放军第八一医院妇产科,江苏南京210002

出　　处：《现代肿瘤医学》2014年第2期402-404,共3页Journal of Modern Oncology

摘　　要：目的:探讨血清细胞质胸苷激酶1(TK1)检测在子宫内膜癌诊治中的临床价值。方法:利用免疫印迹增强化学发光法(ECLA)检测154例子宫内膜癌患者血清TK1的含量,同时检测130例子宫内膜良性疾病和121名健康人血清中的TK1含量。结果:子宫内膜癌患者TK1水平[3.14(1.87-3.95)pmol/L]显著高于子宫内膜良性疾病组[1.31(0.95-1.63)pmol/L]和正常对照组[1.24(0.62-1.49)pmol/L](P<0.01);而子宫内膜良性疾病组和正常对照组之间差异无统计学意义(P>0.05)。154例子宫内膜癌患者手术后血清TK1水平明显下降。子宫内膜癌患者血清TK1阳性率(6 1.7%)远高于其他生殖道肿瘤标志物[癌胚抗原(CEA)(15.6%)]、糖抗原[CA199(14.5%),CA125(17.9%)]。结论:血清TK1检测在子宫内膜癌诊断、预后判断、疗效监测等方面具有一定的临床应用价值。Objectlve：To investigate the diagnostic value of sermn thymidine kinase 1 （sTK1） in endometrimn cancer. Methods：The levds of sTK1 in 154 patients with endometrium cancer, 130 with benign disease and 121 normal controls were determined by enhanced chemi - luminescence assay. Results：The levels of STK1 in patients with endometrimn carcinoma 13.14（ 1.87 -3.95）pmol/L1 were much higher than those in patients with benign disease [1.31 （0.95 - 1. 63 ） pmol/L] and normal eoatrols [1.24 （0.62 - 1. 49 ） pmol/L] （P 〈 0.01 ） , but there was no significant difference between patients with benign disease and normal controls （P 〉 0.05）. The level of STK1 declined significantly one month after operation. The positive rale of STK1 in patients with endometrimn cancer（61.7% ）was much higher than other digestive tmnor marker [ careinoembryonic antigen（CEA） （ 15.6% ） 1 , carbohydrate antigen [ CA199 （ 14.5% ） , CA125 （ 17.9% ） 1 - Conclusion ：The detection of STK1 may have value in the diagnosis, monitoring and prognosis of endometrium cancer.

关 键 词：胸苷激酶 增强化学发光法 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]