以中枢神经系统浸润为首发症状的套细胞淋巴瘤1例并文献复习  

Mantle cell lymphoma with central nervous system infiltration as the initial symptom:a case report and review of literatures

作　　者：侯军[1] 胡晓静[1] 韩颖[1] 孟秀琴[1] 施菊妹[1] 

机构地区：[1]同济大学附属第十人民医院血液科,上海200072

出　　处：《临床血液学杂志》2014年第1期66-68,共3页Journal of Clinical Hematology

基　　金：上海市卫生局资助项目(No:2010081)

摘　　要：1病例资料患者,男,56岁,既往体健,无神经系统疾病史。2012年11月起无明显诱因突发左侧肢体麻木、无力,伴前胸部节段性紧绷感、麻木感,且症状进行性加重,并出现右侧肢体和足底麻木,伴腹胀、嗳气,无口角流涎,无头晕、头痛、胸闷、胸痛、腹痛、呕血及黑便。有盗汗,半年体重下降10kg。A case of 56years old male mantle cell lymphoma（MCL）patient with central nervous system in- filtration as the initial symptom was reported.He had a progressive limbs numbness and weakness firstly and then appeared chest segmental tension.Electromyography showed the neurogenic damage in double arms.Cerebrospinal fluid infiltration was confirmed by a large number of white blood cells（10.0×106/L）and high concentration of protein（1 007mg/L）.Flow cytometry analysis of cerebrospinal fluid revealed 6.7percent of abnormal cells,posi- tive for CD5and negative for CD10expression at the same time.PET-CT demonstrated that there had a mild in- creased intake of FDG in cervical and thoracic spine without obvious destruction in vertebral body.Routine blood test showed that the number of white blood cells was 21.89×10^9/L with 31percent of abnormal cells.Further- more,the laboratory results showed 5percent of blast lymphocytic cells in bone marrow and 38.3percent of mono- clonal mature small B lymphocytic cells with CD5-positive and CD10-negative expression in peripheral blood.FISH showed IGH/CCND1（＋）fusion gene.At last,this patient was diagnosed with MCL.

关 键 词：中枢神经系统浸润 套细胞淋巴瘤 诊断 

分 类 号：R733.4[医药卫生—肿瘤]