长春西汀注射液对老年轻度认知功能障碍超敏C-反应蛋白和白介素-6的影响  

Influence of vinpocetine injection on hs-CRP and IL-6 in elderly patients with mild cognitive impairment

作　　者：吴倩[1] 畅凌 张兰[1] 黄刚[1] 

机构地区：[1]石河子大学医学院第一附属医院老干二科,新疆石河子832008 [2]石河子绿洲医院老年病科,新疆石河子832000

出　　处：《现代医药卫生》2014年第3期349-350,共2页Journal of Modern Medicine & Health

基　　金：新疆生产建设兵团科学技术局资助(2012BA052)

摘　　要：目的探讨长春西汀注射液治疗老年轻度认知功能障碍(MCI)的疗效。方法选择2012年1月至2013年3月老年轻度认知功能障碍患者200例,将其分为长春西汀组和对照组各100例。对照组给予稳定血压、血脂、血糖、改善循环治疗,长春西汀组给予长春西汀注射液30 mg加入5%葡萄糖注射液100 mL,静脉滴注,其余治疗方法同对照组,疗程9 d。治疗前后检查血浆超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)。使用蒙特利尔认知评估量表(Moca)评定疗效。结果长春西汀组治疗后Moca评分较治疗前提高,但差异无统计学意义(P=0.073);长春西汀组hs-CRP、IL-6治疗前后比较,差异有统计学意义(P<0.05);治疗后长春西汀组hs-CRP、IL-6水平均低于对照组,差异有统计学意义(P<0.05)。结论长春西汀注射液可能对老年轻度认知功能障碍有益,这可能与其显著降低血浆hs-CRP、IL-6有关,有待进一步研究。Objective To observe the clinical effect of vinpocetine on mild cognitive impairment （MCI）. Methods A total of 200 senior patients with MCI from January 2012 to March 2013 were selected and randomly divided into vinpocetine group and control group, 100 cases in each group. The control group was with treatment of antihypertension, anti-hyperlipidemia, hyperglycemic and improvement of blood circulation ;while the vinpocetine group was with 30 mg vinpocetine injection and 100 mL 5% glucose injection for intravenous drip on the basis of control group. The course of treatment in the both groups were 9 days. High-sensitivity C-reactive protein （hs-CRP） and interleukin-6 （IL-6） in the two groups before and after treatment were examined. Montreal Cognitive Assessment（Moca） were used to assess the clinical effect. Results The Moca score in the vinpocetine group after treatment was higher than that before treatment, but the difference had no statistical significance （P=0.073）. The difference of hs-CRP and IL-6 in vinpocetine group between before and after treatment had statistical significance （P〈0.05）. The levels of IL-6 and hs-CRP in the vinpocetine group were lower than those in the control group after the treatment with statistically signifciance （P〈0.05）. Conclusion Vinpocetine injection is benificial for senior patients with MCI,which may be related with its effect of reducing plasma hs-CRP and IL-6, so further research is required.

关 键 词：长春花生物碱类 认知障碍 C反应蛋白质 白细胞介素6 

分 类 号：R749.16[医药卫生—神经病学与精神病学]