雷替曲塞治疗老年晚期结直肠癌的疗效分析  

Raltitrexed Therapeutic Efficacy of Elderly Patients with Advanced Colon Cancer

作　　者：张欣[1] 殷瑜[1] 

机构地区：[1]辽宁医学院附属第一医院肿瘤六病区,辽宁锦州121000

出　　处：《医学与哲学（B）》2014年第1期23-24,59,共3页Medicine & Philosophy(B)

摘　　要：比较雷替曲塞与5-氟尿嘧啶联合奥沙利铂治疗老年晚期结直肠癌的临床疗效及生存分析。经病理明确诊断的老年晚期结直肠癌患者42例分为A、B两组,分别采用雷替曲塞和5-氟尿嘧啶/亚叶酸钙联合奥沙利铂方案化疗,观察两组疗效、不良反应及生存分析。结果 A、B两组患者有效率接近,无统计学差异。A、B组疾病进展时间分别是7.5个月和5.2个月,差异有统计学意义(P<0.05)。A、B两组总生存期无明显差异。雷替曲塞联合奥沙利铂方案是老年晚期结直肠癌有效的治疗方案,虽然疗效与5-氟尿嘧啶组接近,但毒性小,用药方便,值得在临床上推广。Compare raltitrexed and 5-fluorouracil and oxaliplatin clinical efficacy of the treatment of elderly patients with advanced colon cancer and prognosis. 42 elderly patients with advanced colon cancer by pathologically diagnosis were divided into group A and group 13, respectively raltitrexed and 5-fluorouracil/leucovorin and oxaliplatin chemotherapy were observed efficacy, adverse reactions and survival analysis. Results of A, B groups of patients with efficiency close, no difference, group A and group B, time to progress was 7.5 months and 5.2 months respectively, a significant difference （P〈0.05）. Group A and group 13, no significant difference in overall survival. Raltitrexed oxaliplatin for advanced colon cancer in elderly effective care program, although the efficacy and 5-fluorouracil group program close to, but less toxic, easy to medication, should be promoted in clinical practice.

关 键 词：雷替曲塞 5-氟尿嘧啶 结直肠癌 奥沙利铂 

分 类 号：R735.3[医药卫生—肿瘤]