CXCR4和CXCR7在甲状腺癌中的表达及病理意义  

Expression and Pathological Significance of the Chemokine Receptor 4 and 7 in Thyroid Cancer

作　　者：高立香 赵树鹏[2] 齐凤杰[3] 尹英爱[1] 

机构地区：[1]辽宁医学院,辽宁锦州121000 [2]辽宁医学院附属第一医院甲状腺血管外科,辽宁锦州121000 [3]辽宁医学院基础医学院病理学教研室,辽宁锦州121000

出　　处：《医学与哲学（B）》2014年第1期52-55,共4页Medicine & Philosophy(B)

基　　金：辽宁省科学技术厅"多发疾病规范化诊疗技术及应用"项目;项目编号:2010225034

摘　　要：研究甲状腺癌组织中趋化因子4受体(CXCR4)和趋化因子7受体(CXCR7)的表达情况及临床病理意义。应用免疫组织化学PV-6000法及Western blot法检测CXCR4与CXCR7在甲状腺癌中的表达。二者在甲状腺癌与甲状腺良性疾病组织的差异均具有统计学意义(P<0.05),在甲状腺癌中表达仅与淋巴结转移有关(P<0.05),CXCR4与CXCR7之间呈正相关。Western blot结果提示二者在甲状腺癌中的表达率高于癌旁及甲状腺腺瘤。CXCR4和CXCR7的表达水平与淋巴结转移相关,可作为甲状腺癌预后的判断指标。To study the expression and pathological significance of the Chemokine receptor 4 （CXCR4） and chemo kine receptor 7 （CXCR7） in thyroid cancer. CXCR4 and CXCR7 expression was analyzed in thyroid cancer tissues by immunohistochemical and Western blot. CXCR4 and CXCR7 in thyroid carcinoma and thyroid benign disease tissues of comparative differences are statistically significant （P〈0.05）. Expression of CXCR4 and CXCR7 in thyroid cancer is only associated with lymph node metastasis （P〈0.05）, Between CXCR4 and CXCR7 were positively correlated. Western blot suggested that CXCR4 and CXCR7 protein expression rate in thyroid carcinoma carcinoma were higher than normal and adenoma. CXCR4 and CXCR7 expression level were associated with lymph node metastasis, which can be used as a prognostic judgment index.

关 键 词：甲状腺癌 趋化因子7受体 趋化因子4受体 趋化因子受体 基质细胞衍生因子-1 

分 类 号：R736.1[医药卫生—肿瘤]