雌激素相关受体α(ERRα)与肿瘤疾病的研究进展  

Research progress on estrogen-related receptorα(ERRα) and tumor diseases

作　　者：陆蕴红[1] 李群益[1] 施孝金[1] 

机构地区：[1]复旦大学附属华山医院药剂科,上海200040

出　　处：《复旦学报（医学版）》2014年第1期126-132,共7页Fudan University Journal of Medical Sciences

基　　金：教育部"高校博士点"科研基金(20110071120071)~~

摘　　要：核受体超家族中的雌激素相关受体(estrogen-related receptor,ERR)是一类无需与配体结合即可产生生物学功能的孤儿受体。近年来研究发现,EER不仅参与雌激素信号转导体系,而且与乳腺癌、前列腺癌等肿瘤疾病有密切关系。ERR主要有3种亚型,ERRα、ERRβ和ERRγ,其中ERRα最受关注。ERRα的表达与雌激素依赖性肿瘤(如乳腺癌、子宫内膜癌)及非雌激素依赖性肿瘤(如胃腺癌,结直肠癌)均密切相关。本文将介绍ERRα与肿瘤疾病相关性的研究进展。Estrogen-related receptor （ERR）,a member of the nuclear receptor superfamily,belongs to orphan nuclear receptor which can generate biological function without ligand binding. ERR is considered closely relating to some tumor disease such as breast cancer and prostate cancer via participating the signal transduction system of estrogen. ERR contains 3 subtypes, ERRa, ERR~ and ERR＇/. ERRs has attracted increasingly concerns and research efforts from all over the world. ERRa expression closely related to estrogen-dependent neoplastic diseases （e. g. breast cancer, endometrial carcinoma） and estrogen-independent neoplastic diseases （e. g. adenocarcinoma of stomach, colorectal cancer）. This review reveals the research progress on the correlation between ERRs and tumor diseases.

关 键 词：ERRα 肿瘤 乳腺癌 子宫内膜癌 前列腺癌 胃腺癌 

分 类 号：R730.231.3[医药卫生—肿瘤]