加减驻景方联合雷珠单抗治疗高度近视性黄斑出血  

Modified Zhujing Formula combined with Lucentis in treating macula hemorrhage of pathological myopia

作　　者：刘彦江[1] 张月[1] 亢泽峰[1] 田楠楠[1] 张庆[1] 李满[1] 侯静梅[1] 高娜[1] 沈志华[1] 

机构地区：[1]中国中医科学院眼科医院,中国北京市100040

出　　处：《国际眼科杂志》2014年第2期313-316,共4页International Eye Science

基　　金：北京市中医管理局(No.JJ2011-71)~~

摘　　要：目的:观察加减驻景方治疗高度近视黄斑出血的临床疗效。方法:将患者42例42眼根据治疗方法不同分为加减驻景方组25例25眼,用加减驻景方治疗;加减驻景方联合雷珠单抗组(联合组)17例17眼,采用玻璃体腔内注射雷珠单抗同时给予加减驻景方进行治疗,治疗前后采用OCT检测中心视网膜厚度,随访3mo,观察两组的疗效。结果:联合组在治疗3mo后总有效率达到82%,加减驻景方组总有效率达到60%;联合组在治疗3mo后眼底出血吸收总有效率达88%,加减驻景方组的有效率达64%;在降低中心视网膜厚度方面,各组治疗后与治疗前比较及两组组间比较,差异均有统计学意义(P<0.05)。结论:中药加减驻景方能有效地延缓病情的发展、减少病变的反复次数及提高患者的视力。AIM： To investigate the clinical effect of Modified Zhujing Formula combined with Lucentis on treating macular hemorrhage of pathological myopia. METHODS： Forty-two patients （42 eyes） were divided into 2 groups：Modified Zhu Jing Formula group, 25 cases （25 eyes）, were treated with Modified Zhu Jing Formula, and combined treatment group administrated Modified Zhu Jing Formula with intravitreal Lucentis injection （17 eyes in 17 cases）. Central retinal thickness was measured by optical coherence tomography before and after the treatment. Three months after the treatment, the therapeutic effect was observed. RESULTS： Three months after the treatment, the total effective rate of combined treatment group was 82%, while that of Modified Zhu Jing Formula group was 60%. The total effective rate of fundus hemorrhage absorption for combined treatment group was 88%, while that of Modified Zhu Jing Formula group was 64%. In terms of reducing central retinal thickness, the difference betweenpre-treatment and post-treatment for each group and the difference between two groups were both significant （ P〈 0.05）. CONCLUSION： Modified down disease progression, improve patients＇ vision. Zhu Jing Formula can slow decrease recurrent risk and

关 键 词：加减驻景方 雷珠单抗 高度近视黄斑出血 

分 类 号：R778.11[医药卫生—眼科]