胰腺神经内分泌癌60例临床病理特征及外科治疗策略  

Clinicopathological features and surgical treatment strategies of pancreatic neuroendocrine carcinoma

作　　者：郑楷炼[1] 彭智勇[1] 胡先贵[1] 金钢[1] 邵成浩[1] 张怡杰[1] 周颖奇[1] 周旭宇[1] 刘瑞[1] 

机构地区：[1]第二军医大学附属长海医院胰腺外科,上海200433

出　　处：《中华肝胆外科杂志》2014年第1期32-34,共3页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的探讨胰腺神经内分泌癌（PNEC）的临床病理学特征与外科治疗效果.方法回顾性分析长海医院1998年1月至2011年11月手术治疗的60例PNEC患者的临床病理学特征与外科治疗效果,采用log-rank检验比较根治性切除组与姑息性手术组患者生存情况之间的差异.结果60例患者中行根治性切除者50例,行姑息性手术者10例.根治性切除组5年生存率达51.5％,非根治性切除组的3年生存率为10.0％.根治性切除组的中位生存时间为61个月,非根治性切除组的中位生存时间为16个月（P＜0.01）.结论手术是治疗PNEC的首选方法,根治性切除组比姑息性切除组生存时间长.Objective To investigate the clinicopathological features and the effect of surgical treatment on pancreatic neuroendocrine carcinoma （PNEC）.Methods The clinical data of 60 patients with PNEC treated from January 1998 to November 2011 at Changhai Hospital were retrospectively analyzed.The differences in survival rates and the duration of survival between the radical resection group and the palliative surgery group were compared with the log-rank test.Results Of 60 patients,50 received radical resection and 10 palliative surgery.The 5-year overall survival for the radical resection group was 51.5%.The overall survival at 3 years for the palliative surgery group was 10.0%.The median survival was 61 months for the radical resection group and 16 months for the palliative surgery group （P 〈 0.01）.Conclusions Surgery is the first choice of treatment for PNEC.The survival of the radical resection group was significantly longer than that of the palliative surgery group.

关 键 词：胰腺肿瘤 病理学 外科手术 存活率 

分 类 号：R735.9[医药卫生—肿瘤]