脑肠肽与肠易激综合征相关性研究进展  

Research Progress on Understanding Relationship between Neuropeptides and Irritable Bowel Syndrome

作　　者：史瑞瑞[1] 王晶[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《世界科学技术-中医药现代化》2013年第8期1747-1750,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81073132):缬草醚醛对肠易激综合征(IBS)的治疗作用及5-HT通路调控的实验研究;负责人:闫兴丽;北京中医药大学校级自主课题(2013JYBZZXS102):蜘蛛香提取物对肠易激综合征(IBS)5-HT通路肠嗜铬细胞;5-羟色胺转运体表达的调控作用研究;负责人:史瑞瑞

摘　　要：肠易激综合征的发病机制目前尚未完全阐明。胃肠动力异常和内脏高敏性是其主要的病理生理学基础。脑肠肽的异常表达可通过影响内脏感觉、分泌和运动,导致肠易激综合征发生。本文从5-羟色胺、促肾上腺皮质激素释放因子、血管活性肠肽、P物质、生长抑素等脑肠肽入手,探讨脑肠肽与肠易激综合征的相关性,为明确肠易激综合征的发病机制提供参考依据。The pathogenesis of irritable bowel syndrome（IBS） has not been fully elucidated. Abnormal gastrointesti-nal dynamics and visceral hypersensitivity were its main pathophysiological basis. Abnormal expression of neu-ropeptides can affect the visceral sensation, secretion and movement, leading to the occurrence of IBS. This article reviewed the relationship between neuropeptides and IBS from the following neuropeptides： 5-hydroxytryptamine （5-HT）, corticotropin releasing factor （CRF）, vasoactive intestinal peptide （VIP）, substance P （SP）, and somatostatin （SS）. It provided reference evidences for the elucidation of IBS pathogenesis.

关 键 词：肠易激综合征 脑肠肽 研究进展 

分 类 号：R574.4[医药卫生—消化系统]