TRPM8与肿瘤的研究进展  

TRPM8 channel in neoplasms

作　　者：温自强[1] 王洪成[1] 黄新余[1] 

机构地区：[1]上海交通大学附属第六人民医院普外科,上海200233

出　　处：《国际外科学杂志》2014年第1期42-46,共5页International Journal of Surgery

摘　　要：瞬时受体电位（TRP）通道影响一些炎症反应和肿瘤的发生、发展.TRP通道分布广泛,调节机制各异,通过感受细胞内外环境的各种刺激,参与痛觉、机械感觉、味觉的发生和维持细胞内外环境的离子稳态等众多生命活动,具有调节肌肉收缩、递质释放、细胞增生、细胞分化、基因转录、细胞凋亡及细胞死亡等作用.TRP通道亚型TRPM8是一种非选择性阳离子通道,最初作为一种前列腺特异性蛋白被克隆出来,现发现在结肠癌、肺癌、乳腺癌、胰腺癌以及皮肤来源的恶性肿瘤中均有表达.这篇综述旨在概述TRPM8在不同类型肿瘤中的表达和功能.Transient receptor potential （TRP） channels affect several inflammatory and neoplastic conditions.and are widely distributed and activated by multiple stimuli.Mean while,as the sensor to the changes in cellular local environments,TRP channels have multiple functions,including thermal,mechanical and taste sensing,as well as ion homeostasis maintaining.They can regulate muscle contractions,transmitter release,cell multiplication,cell differentiation,genetic transcription,apoptosis and molecular death.TRPM8,a nonselective cation channel,was originally cloned as a prostate-specific protein.Now,TRPM8 is found in carcinoma of colon,lung cancer,mammary cancer,pancreatic cancer and cutaneum carcinoma.The aim of this review is to summarize data reported so far on the expression and functional role of TRPM8 channels in different types of cancers.

关 键 词：TRPM8 增生 肿瘤 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]