促炎细胞因子在胃癌前病变中的作用  

Roles of proinflammatory cytokines in precancerous lesions of gastric cancer

作　　者：王冬青[1] 丁西平[1] 殷实 

机构地区：[1]安徽医科大学附属省立医院消化内科,安徽省合肥市230001 [2]安徽医科大学附属省立医院老年病科,安徽省合肥市230001

出　　处：《世界华人消化杂志》2014年第1期39-45,共7页World Chinese Journal of Digestology

摘　　要：胃癌前病变是一个病理性概念,包括肠上皮化生和异型增生,是从正常胃组织向胃癌转化过程中的一个重要阶段.胃癌有很高的死亡率主要是由于其转移后才被诊断,故对胃癌前病变的研究尤为重要.近年来,随着胃癌前病变的研究不断深入,发现一些促炎细胞因子如白介素-1β(interleukin 1 beta,IL-1β)、IL-8、IL-11、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、干扰素γ(interferonγ,IFN-γ)在胃癌前病变中发挥重要的作用.而这些促炎细胞因子的详细作用机制,可能为胃癌前病变的治疗提供新的方法.故本文针对几种促炎细胞因子在胃癌前病变中的作用作一综述.Precancerous lesions of gastric cancer, including intestinal metaplasia and dysplasia, are important stages in the evolution from normal gastric tissue to gastric cancer. Gastric cancer has a very high mortality rate, mainly due to post-metastasis diagnosis. Therefore, diagnosis of precancerous lesions of gastric cancer is of great clinical significance. In recent years, it has been reported that some proinflammatory cytokines such as interleukin 1β （IL-1β）, IL-8, IL-11, tumor necrosis factor α （TNF-α） and interferon-gamma （IFN-γ） play important roles in the development of precancerous lesions of gastric cancer. A more detailed understanding of the roles of proinflammatory cytokines may provide new therapeutic targets for precancerous lesions of gastric cancer. Here, we summarize the roles of some proinflammatory cytokines in the progression of precancerous lesions of gastric cancer.

关 键 词：促炎细胞因子 胃癌前病变 异型增生 肠上皮化生 

分 类 号：R735.2[医药卫生—肿瘤]