特异性核基质结合区结合蛋白1在消化系肿瘤中的研究进展  

Role of special AT rich sequence binding protein 1 in digestive system neoplasms

作　　者：毕洪钟 王伟[1] 胡敏敏[1] 琚坚[1] 

机构地区：[1]昆明医科大学第二附属医院特需病房科,云南省昆明市650101

出　　处：《世界华人消化杂志》2014年第1期67-73,共7页World Chinese Journal of Digestology

摘　　要：特异性核基质结合区结合蛋白1(special AT rich sequence binding protein 1,SATB1)又称AT富集序列特异性结合蛋白1,是一种独特的全局调节因子,通过基因表达调控结合染色质高级结构,对染色质进行表观遗传修饰和动态改变,直接调节促癌基因的表达.自2008年在乳腺癌细胞中发现他对肿瘤细胞的发生和转移有促进作用后,近年来又发现其高表达对消化系肿瘤(包括口腔癌、胃癌、肝癌、胆囊癌、结直肠癌)的肿瘤细胞增殖、侵袭、转移关系密切.我国以消化系肿瘤多见,如何控制恶性肿瘤的转移,一直是国内外研究的重点.随着对SATB1作用机制的深入研究必将为恶性肿瘤的诊断、治疗以及预后评估提供新的思路和方法.本文就近年来SATB1在消化系肿瘤中的相关研究进展作一综述.Special AT rich sequence binding protein 1 （SATB1） is a unique global regulatory factor. Epigenetic modifications and dynamic changes in chromatin organization mediated by SATB1 have recently been shown to play an important role in regulating cancer-promoting genes. The role of SATB1 in promoting metastasis was discovered in breast carcinoma cells in 2008. In recent years, high expression of SATB1 has been found in digestive system neoplasms including oral cancer, stomach cancer, liver cancer, gallbladder cancer and colorectal cancer. SATB1 is related closely to proliferation, invasion and metastasis of tumor cells. Digestive system neoplasms are the most common malignant tumor in China, and control of cancer metastasis has been the research focus. A better understanding of the role of SATB1 will contribute to the diagnosis, treatment and prognosis evaluation in malignant tumors. In this review, we will summarize recent progress in understanding the role of SATB1 in digestive system neoplasms.

关 键 词：特异性核基质结合区结合蛋白质1 消化系肿瘤 转移 机制 

分 类 号：R735[医药卫生—肿瘤]