2,4,5-三氟苯乙酸的合成  

Synthesis of 2, 4, 5-Trifluorophenylacetic Acid

作　　者：鲍樟水[1] 冯启[1] 夏旭建[1] 郑昀红[1] 孔小林[1] 

机构地区：[1]浙江省化工研究院有限公司,浙江杭州310023

出　　处：《浙江化工》2014年第1期4-6,共3页Zhejiang Chemical Industry

摘　　要：以1,2,4,5-四氟苯和氰乙酸乙酯为原料,经过取代反应、水解脱羧反应制备得到2,4,5-三氟苯乙酸。该法操作简单、反应路线短、不使用剧毒氰化物,为合成2,4,5-三氟苯乙酸提供了新的途径。2, 4, 5-Trifluorophenylacetic acid was synthesized from 1, 2, 4, 5-tetrafluorobenzene and ethyl cyanoacetate according to the substitution and the hydrolysis decarboxylation processes. This method was easily handled, the reaction route was short, and no toxic cyanide was used, which provide a new pathway to 2, 4, 5-trifluorophenylacetic acid.

关 键 词：2 4 5-三氟苯乙酸 氰乙酸乙酯 西他列汀 合成 

分 类 号：TQ245.3[化学工程—有机化工]