傅里叶变换红外光谱学显微成像技术在骨病研究中的应用和进展  

Applications and Progress of Fourier Transform Infrared Spectroscopic Microimaging in Bone Disease Research

作　　者：尹建华[1] 黄凤玲[1] 钱志余[1] 谢捷如[1] 

机构地区：[1]南京航空航天大学自动化学院生物医学工程系,江苏南京210016

出　　处：《光谱学与光谱分析》2014年第2期340-343,共4页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(61275199;61378087);南京航空航天大学引进人才科研启动基金项目(1003-56YAH13005)资助

摘　　要：傅里叶变换红外光谱学显微成像系统的发展历程、系统构成、成像原理和模式选择,引出傅里叶变换红外光谱学显微成像在生物医学领域开辟了骨病光谱成像这一特定研究方向,详细论述了该技术用于研究骨石化病、成骨不全症、骨质疏松症和骨软化症等骨病所取得的成果和进展,简单介绍了该技术的相关局限性,并展望了其在生物医学研究领域的发展前景。Fourier transform infrared spectroscopy （FTIRS） and microimaging technique have been integrated together to evolve into Fourier transform infrared spectroscopic imaging （FTIRI） system .This system can provide not only the morphological in-formation of the sample by visible image and FTIR image ,but also the abundant information on the spectral ,component and structure of specimen by FTIRS ,especially of the heterogeneous solid mixture .The richer and more visualized information obtained by FTIRI greatly raised the research efficiency and usability of the spectral technique in biomedicine ,pharmacology , forensic medicine ,material science and chemistry ,etc .The present paper depicts FTIRI development process ,system structure , imaging principle and mode selection ;and then introduces that FTIRI opened a new area of investigation for biomedicine ,name-ly ,research on bone disease by FTIRI .Then the paper illustrates the related research findings and progress in FTIRI use for osteopetrosis ,osteogenesis imperfecta ,osteoporosis and osteomalacia ,as well as a couple of limitations .The prospective study for FTIRI in biomedical research field is also addressed .

关 键 词：傅里叶变换红外光谱 显微成像 高分辨 骨病 FOURIER TRANSFORM infrared spectroscopy (FTIRS) 

分 类 号：O657.3[理学—分析化学] Q-3[理学—化学]