急性肝衰竭患者血清炎性细胞因子水平分析  

Serum inflammatory cytokines levels in patients with acute liver failure

作　　者：赵攀[1] 毕振华[2] 王春亚[3] 

机构地区：[1]解放军第302医院肝衰竭诊疗与研究中心,北京市100039 [2]解放军第302医院麻醉与手术中心,北京市100039 [3]首都医科大学附属北京安贞医院急诊科

出　　处：《实用肝脏病杂志》2014年第1期63-64,共2页Journal of Practical Hepatology

摘　　要：目的探讨急性肝衰竭患者血清炎性细胞因子水平的变化。方法选择15例急性肝衰竭患者和15例健康人,采用Cytometric Bead Array法检测血清细胞因子。结果急性肝衰竭患者和健康人血清IL-2、IL-4、IL-5、IL-12p70和TNF-β水平无统计学差异;急性肝衰竭患者血清TNF-α(13.49 pg/mL)、IL-6(480.96 pg/mL)、IL-10(330.28 pg/mL)和IL-17(6.36 pg/mL)水平显著高于健康人(TNF-α为7.32 pg/mL,P=0.03;IL-6为4.64pg/mL,P<0.01;IL-10为5.47pg/mL,P<0.01;IL-17为2.03 pg/mL,P=0.04)。结论炎性细胞因子在急性肝衰竭发病的病理过程中可能起了重要作用。Objective To study the changes in serum inflammatory cytokines in patients with acute liver failure （ALF）. Methods Fifteen patients with ALF in our hospital from June 2011 to June 2013 were included in this study,and 15 healthy subjects were served as normal controls. Serum levels of interleukin （IL）-2,IL-4, I L-5,IL-6,IL-10,IL-17,IL12p70,tumor necrosis factor（TNF）-α and TNF-β were measured by cytometric bead array. Results No statistical differences were observed between ALF patients and healthy controls in serum IL-2,IL-4,IL-5,IL-12p70 and TNF-βlevels;The serum level of TNF-α,IL-6,IL-10 and IL-17 in patients with ALF were 13.49 pg/mL,480.96 pg/mL,330.28 pg/mL and 6.36 pg/mL,respectively,significantly higher than those in healthy con-trols（7.32pg/mL for TNF-α,P=0.03;4.64 pg/mL for IL-6,P＆lt;0.01;5.47 pg/mL for IL-10,P＆lt;0.01;and 2.03 pg/mL for IL-17,P=0.04）. Conclusion Inflammatory cytokines play a significant role in the pathophysiology of ALF.

关 键 词：急性肝衰竭 炎性细胞因子 血清 

分 类 号：R575.3[医药卫生—消化系统]