晚期非小细胞肺癌组织中LRP表达与铂类耐药性及预后的相关性研究  

Study on correlation among expression of LRP and platinum resistance and prognosis in advanced non-small cell lung cancer

作　　者：刘琼[1] 黄昌杰[2] 黄文锋[2] 湛永滋[2] 黄剑锋[2] 王湘萍[2] 

机构地区：[1]广西医科大学研究生学院,南宁530021 [2]广西医科大学第三附属医院肿瘤科(南宁市第二人民医院),南宁530031

出　　处：《中国临床新医学》2014年第1期1-4,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金资助项目(编号:2010GXNSFA013260);南宁市科学研究与技术开发计划项目(编号:201003045C-6)

摘　　要：目的探讨晚期非小细胞肺癌(NSCLC)组织中肺耐药蛋白(LRP)的表达与铂类化疗耐药及其预后的关系。方法采用免疫组织化学SP法对89例晚期NSCLC碏块进行免疫组织化学染色,检测LRP的表达水平,并分析其与患者的性别、年龄、吸烟史、组织分型、分化程度、远处转移、淋巴结转移及含铂化疗方案疗效的关系。结果在NSCLC患者组织中,LRP的阳性表达率为77.5%,与年龄、吸烟史、组织分型、分化程度和淋巴结转移无关(P均>0.05),而LRP表达阳性组和阴性组的含铂类方案化疗疗效、有效率、总反应率、无进展生存时间和总生存时间比较差异无统计学意义(P均>0.05)。女性患者肿瘤组织LRP表达阳性率(95.5%)高于男性患者(71.6%)(P=0.043);在远处转移的患者中,LPR阳性表达率为87.3%,而无远处转移的患者LRP阳性表达率为61.8%,差异有统计学意义(P=0.005)。结论 LRP基因的阳性表达与远处转移有关,且LRP阳性表达患者无疾病进展时间及总生存时间均低于LRP阴性表达患者,提示其可能作为判断预后指标。Objective To study the expression of lung resistance protein （LRP） in non-small cell Lung Cancer（NSCLC） and its correlation with Platium resistance and prognosis .Methods The expression of LRP in 89 NSCLC patients was detected by the way of immunohistochemical method .The relationship between LRP and clinico-pathological feature and the others （age, sex, smoking history, histological type, differentiation, distant metastasis, lymphatic metastasis and so on ） were studied .Results In the tissues of patients with NSCLC , the positive express-ing rate of LRP was 77.5%, and was not related with age , sex, smoking history, histological type, differentiation, distant metastasis , lymphatic metastasis （ P〉0.05 ） .In the platinum contained chemotherapy regimens , there were not statistical significant difference in RR , DCR, PFS, and OS between the LRP positive expression group and the LRP negative expression group （ all P〉0.05 ） .The positive expression rate of LRP in female patients （ 95.5%） was higher than that in male patients（71.6%;P=0.043）.The positive expression rate in the patient with distant metas-tasis（87.3%） was higher than that in the patients without distant metastasis （61.8%）（P=0.005）.Conclusion The positive expression of LRP is related to the diagnosis distant metastasis of NSCLC .The PFS, OS in LRP-positive patients are lower than those in LRP negative patients .These results suggest LRP may be an evaluating indicator of the prognosis of NSCLC .

关 键 词：非小细胞肺癌 肺耐药蛋白 顺铂 耐药 预后 

分 类 号：R730[医药卫生—肿瘤]