氟比洛芬用于婴幼儿腭裂修复术后镇痛效果和安全性的研究  

ANALGESIC EFFECT AND SAFENESS OF FLURBIPROFEN AXETIL ON INFANTS AFTER PALATORRHAPHY

作　　者：焦亮[1] 刘瑞昌[1] 

机构地区：[1]北京大学口腔医院麻醉科,北京100081

出　　处：《中国疼痛医学杂志》2014年第1期26-29,共4页Chinese Journal of Pain Medicine

摘　　要：目的:观察氟比洛芬用于婴幼儿术后镇痛的效果,初步探讨其安全性。方法:腭裂修复术的婴幼儿患者60例,分为两组,氟比洛芬组(F组)术毕前30min静脉给药1mg/kg,对照组(C组)不给镇痛药物。记录拔管后10min、30min、60min患儿的EDIN疼痛评分及HR,术后1h检测血小板聚集功能(PAG)。结果:与C组比较,F组患儿三个时点的EDIN评分、HR均明显降低。F组术后1 h的PAG与术前比较无显著性差异。结论:氟比洛芬镇痛作用显著,对于血小板聚集功能无明显影响,是婴幼儿术后镇痛安全用药的新选择。Objective： To observe the analgesia effect of flurbiprofen on infants after palatorrhaphy and discuss its safeness preliminarily. Methods： 60 infants with cleft palate were divided into 2 groups, which were flurbiprofen group （group F） and control group （ group C ） . Flurbiprofen （lmg/kg） was administered intravenously on infants in group F 30 minutes before the end of the operation. Group C received nothing. I^chelle Douleur Inconfort Nouveau-N6 （ EDIN ） scales and HR were recorded at the time of 10, 30, 60 minutes after extubation. Platelet aggregation was detected at the time of lh after operation. Results： Compared with group C, EDIN scales and HR of group F after extubation were decreased significantly. Compared with preoperative results, PAG of group F at the time of lh after operation had not a significant change. Conclusion： Flurbiprofen has notable analgesia effect and it has not significant influence on PAG, so it is a better choice to carry out postoperative analgesia for infants.

关 键 词：氟比洛芬 婴幼儿 腭裂修复术 镇痛 安全 

分 类 号：R782.054[医药卫生—口腔医学]