神经节苷脂联合神经生长因子治疗小儿脑损伤的效果观察  

Observation of the ganglioside combined with nerve growth factor in the treatment of children brain damage

作　　者：陈桃[1] 郭渠莲[1] 

机构地区：[1]泸州医学院附属医院儿二科,四川泸州646000

出　　处：《中国妇幼保健》2014年第5期728-730,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨神经节苷脂联合神经生长因子治疗小儿脑损伤的临床效果。方法：选取该院2009年10月～2012年12月诊治的小儿脑损伤患者85例，根据治疗方法分为两组，41例患儿在常规治疗基础上行胞二磷胆碱治疗为对照组，44例患儿在常规治疗基础上行神经节苷脂联合神经生长因子治疗为观察组，治疗时间为16天，比较两组患儿的临床指征恢复时间、神经行为功能评分及临床疗效。结果：随着时间的推移，两组患儿神经行为功能评分均显著提升。观察组患儿在治疗2天时神经行为功能评分（22．8±1．7）分高于对照组（21．3±2．2）分，但差异无统计学意义（P〉0．05）。观察组患儿在治疗4天时神经行为功能评分（30．9±2．6）分、8天（35．2±3．1）分、16天（38．9±4．6）分均明显高于对照组（25．7±2．5）分、（30．1±3．0）分、（33．4±3．9）分，观察组患儿意识恢复时间（4．3±1．2）天、反射恢复时间（5．6±1．4）天、肌张力恢复时间（7．3±1．8）天均明显小于对照组（6．4±1．8）天、（7．8±2．0）天、（9．7±2．1）天，观察组总有效率（97．73％）明显高于对照组（85．36％），差异均有统计学意义（P〈0．05）。结论：神经节苷脂联合神经生长因子是治疗小儿脑损伤的有效方法，可明显缩短患儿的治疗时间，改善患儿的神经行为功能，提高治疗效果，值得临床推广使用。Objective： To investigate the clinical effect of ganglioside combined with nerve growth factor in the treatment of children with brain injury. Methods： 85 cases of brain damage children in the hospital from October 2009 to December 2012, according to treatment methods, were divided into two groups, 41 patients in the conventional treatment on the basis of cytoplasmic two choline treatment for the control group, 44 patients in the conventional treatment on the basis of ganglioside combined with nerve growth factor in the treatment as the observation group, treatment time was 16 days. Children with indication of recovery time, neurobehavioral score and the clinical efficacy were compared. Results： With the passage of time, neurological function score of children in two groups was significantly improved. The neurobehavioral function score of observation group patients in the treatment of 2 d was higher than that of the control group （22. 8 ± 1.7 vs 21.3 ±2. 2）, but there was no significant difference （P 〉0. 05） . The neurobehavioral score of observation group patients in the treatment of 4, 8, 16 d were significantly higher than those of the control group [ （30. 9±2. 6）, （35.2 ± 3. 1 ）, （ 38.9 ± 4. 6） vs （25.7 ±2. 5）, （30. 1 ±3）, （33.4 ±3.9）] . Consciousness recovery time （4. 3 ± 1.2） d, reflex recovery time （5.6 ± 1.4） d, muscle tension recovery time （ 7. 3 ± 1.8 ） d in observation group were significantly less than those of the control group （ 6.4 ± 1.8 ） d, （ 7.8 ± 2.0） d, （9.7 ± 2. 1 ） d, total effective rate in the observation group （97.7%） was significantly higher than that of control group （ 85.4% ）, the differences were statistically significant （ P 〈 0. 05 ） . Conclusion ： Ganglioside combined with nerve growth factor is an effective method for treatment of children with brain damage in children, can significantly shorten the treatment time, improve the neurobehavioral function of children, improve the therapeutic

关 键 词：神经节苷脂 神经生长因子 小儿 脑损伤 

分 类 号：R742[医药卫生—神经病学与精神病学]