β细胞素在肝癌中的表达及其与肝癌侵袭能力的相关性研究  

The expression of BTC protein in hepatocellular carcinoma and study of the related factors

作　　者：李军[1] 高远[1] 张光亚[1] 安家泽 窦科峰[1] 

机构地区：[1]第四军医大学西京医院肝胆外科,西安710032

出　　处：《陕西医学杂志》2014年第2期158-159,251,共3页Shaanxi Medical Journal

基　　金：陕西省社会发展攻关计划项目[2009K12-02(9)]

摘　　要：目的:检测β细胞素(BTC)在肝癌组织及癌旁组织中的表达并探讨其与肝癌侵袭能力的相关性。方法:采用免疫组织化学法检测BTC在肝癌组织和癌旁组织中的表达水平。结果:BTC在肝癌组织中的表达与癌旁组织相比存在高表达的现象,且肿瘤直径≥3cm和有包膜浸润的肝癌组织中BTC也存在高表达的现象,而且这些差异有统计学意义(P<0.05)。结论:BTC表达与肝癌的增殖、侵袭能力密切相关,可能在肝癌发生、发展过程中起着重要的作用。Objective：To investigate the BTC protein expression in hepatocellular carcinoma tissue and tissue around the lesion and to analyze its related clinical factors .Methods ：To detect the BTC protein expression by immunohistochemistry .Results ：BTC protein expression in HCC tissue is higher than it in tissue around the lesion , and its protein expression is higher in the lesion whose diameter is bigger than 3cm and which shows capsular inva-sion .Conclusion：BTC expression is closely associated with the proliferation and invasion of HCC ,it may play an im-portant role in the generation and development of HCC .

关 键 词：肝肿瘤 免疫组织化学 Β细胞素 

分 类 号：R737.5[医药卫生—肿瘤]