细菌抑制法筛查新生儿苯丙酮尿症的分析  

Analysis of screening for neonatal phenylketonuria by bacteria inhibition method

作　　者：刘革伟 许剑虹[2] 王艳丽[2] 

机构地区：[1]鞍山市妇幼保健所保健科,辽宁鞍山114002 [2]鞍山市妇幼保健所新筛实验室,辽宁鞍山114002

出　　处：《中华医院感染学杂志》2014年第3期772-774,共3页Chinese Journal of Nosocomiology

基　　金：卫生部人才支持计划基金项目(2010B-0019)

摘　　要：目的分析细菌抑制法筛查新生儿苯丙酮尿症（PKU）情况，以促进新生儿苯丙酮尿症的早期干预及指导。方法回顾性分析2012年1月～6月11950例新生儿采用细菌抑制法筛查苯丙酮尿症的临床资料。结果所有的日龄中以3～5d的复查率最低，但是其有1例检出有苯丙酮尿症，检出率为0．22‰，而低体重出生儿苯丙酮尿症的发生率高，复查率18．5％。结论细菌抑制法筛查新生儿苯丙酮尿症操作简单、成本低廉、结果可靠，但应注意选择筛查时机，确保得到更为准确可靠的结果。OBJECTIVE To analyze the status of screening for neonatal phenylketonuria （PKU） by bacteria inhibition method, and to promote the early intervention and instruction of neonatal phenylketonuria. METHODS A retrospective analysis was conducted on the clinical data of 11,950 patients with neonatal phenylketonuria screened by the bacterial inhibition method from Jan. to Jun. 2012. RESULTS The review rate of the neonate of 3 to 5 days was the lowest among all the rates in neonate, but PKU was detected in one patient, and the detection rate was 0.22‰. The incidence of PKU in low birth weight was high and the review rate was 18. 5%. CONCLUSION The screening for neonatal phenylketonuria by bacteria inhibition method is easy to operate and has low cost and reliable results, but more attention should be paid to the timing of screening in order to ensure the results to be more accurate and reliable.

关 键 词：细菌抑制法 新生儿 苯丙酮尿症 

分 类 号：R446[医药卫生—诊断学]