STAT3与肿瘤免疫逃逸的研究进展  

Progress in the study of relationship between STAT3 and tumor immune escape

作　　者：祝宝让[1] 杨武威[1] 

机构地区：[1]军事医学科学院附属医院肿瘤微创治疗科,北京100071

出　　处：《中华临床医师杂志（电子版）》2013年第22期159-161,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(30801352)

摘　　要：信号转导子与转录激活子3(STAT3)是一种存在于细胞质内的双功能蛋白,可以被多种酪氨酸激酶激活,激活后发生磷酸化,形成二聚体转入细胞核内,调节细胞生长、分化、凋亡相关基因的表达,是多条致癌通路的汇集点,在大多数肿瘤细胞内呈持续性激活,在肿瘤的发生、发展、转移中起了重要作用。近几年的研究表明,STAT3能在很多环节参与调节肿瘤的免疫逃逸,可能是肿瘤免疫治疗的一个重要靶点。Signal transducer and activator of transcription 3 is a dual function of protein in the cytoplasm, which is constitutively activated at a very high frequency in human cancer, on phosphorylation of STAT3 monomers by tyrosine kinases, the monomers dimerized, translocate to the nucleus, and bind to specific promoter sequences, thereby inducing expression of multiple genes associated with cellular proliferation and survival, which is a point of convergence for many oncogenic pathways, play a crucial role in tumor initiation and progression. In recent study, STAT3 has emerged as a critical mediator of tumor immune evasion at multiple levels, provide a target for cancer immunotherapy.

关 键 词：STAT3 肿瘤 免疫逃逸 免疫治疗 

分 类 号：R730.3[医药卫生—肿瘤]